2-[(2-hydroxyethyl)oxy]ethyl [2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]{3-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-isoxazolyl}acetate

Base Information

Chemical Name:2-[(2-hydroxyethyl)oxy]ethyl [2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]{3-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-isoxazolyl}acetate
CAS No.:1268383-48-7
Molecular Formula:C₃₀H₂₆F₅N₅O₆
Molecular Weight:647.558
Hs Code.:

2-[(2-hydroxyethyl)oxy]ethyl [2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]{3-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-isoxazolyl}acetate

Synonyms:2-[(2-hydroxyethyl)oxy]ethyl [2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]{3-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-isoxazolyl}acetate

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Chemical Property of 2-[(2-hydroxyethyl)oxy]ethyl [2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]{3-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-isoxazolyl}acetate

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Technology Process of 2-[(2-hydroxyethyl)oxy]ethyl [2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]{3-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-isoxazolyl}acetate

There total 20 articles about 2-[(2-hydroxyethyl)oxy]ethyl [2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]{3-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-isoxazolyl}acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1268383-41-0
methyl [2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]{3-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-isoxazolyl}-acetate

: 111-46-6
diethylene glycol

: 1268383-48-7
2-[(2-hydroxyethyl)oxy]ethyl [2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]{3-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-isoxazolyl}acetate

Guidance literature:: With triethylamine; In Isopropyl acetate; at 20 ℃; for 3h; Inert atmosphere; Large scale;
DOI:10.1021/jo4014595

Reference yield: 76.0%

: 1268383-48-7
2-[(2-hydroxyethyl)oxy]ethyl [2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]{3-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-isoxazolyl}acetate

Guidance literature:

Reference yield:

: 2646-91-5
2,3-difluorobenzaldehyde

: 1268383-48-7
2-[(2-hydroxyethyl)oxy]ethyl [2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]{3-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-isoxazolyl}acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: ammonium acetate / water; isopropyl alcohol / 6 h / 25 °C / Inert atmosphere; Large scale

2.1: potassium hydroxide / water / 0.17 h / 25 °C / Inert atmosphere; Large scale

2.2: 10 h / 25 - 50 °C / Inert atmosphere; Large scale

3.1: Pt(5%)Bi(5%)/C; sodium hydroxide / water; acetonitrile / 5 h / 23 - 45 °C

4.1: hydrogen bromide / ethyl acetate / 1 h / 20 °C / Inert atmosphere

5.1: triethylamine / Isopropyl acetate / 3 h / 20 °C / Inert atmosphere; Large scale

With Pt(5%)Bi(5%)/C; ammonium acetate; hydrogen bromide; triethylamine; potassium hydroxide; sodium hydroxide; In Isopropyl acetate; water; ethyl acetate; isopropyl alcohol; acetonitrile;
DOI:10.1021/jo4014595