Technology Process of 6-[3-(4-fluoro-phenyl)-5-methyl-3H-[1,2,3]triazol-4-ylmethoxy]-pyridazine-3-carboxylic acid ethyl ester
There total 7 articles about 6-[3-(4-fluoro-phenyl)-5-methyl-3H-[1,2,3]triazol-4-ylmethoxy]-pyridazine-3-carboxylic acid ethyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
ethanol; 3-chloro-6-[3-(4-fluoro-phenyl)-5-methyl-3H-[1,2,3]triazol-4-ylmethoxy]-pyridazine;
With
sodium carbonate;
1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate;
Inert atmosphere;
carbon monoxide;
at 50 ℃;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: trifluoroacetic acid; sodium azide; sodium nitrite; sulfuric acid / water / 1.5 h / 10 - 18 °C / Cooling with ice
2.1: hexane / 144 h / 20 °C / Cooling with ice; Darkness
3.1: potassium hydroxide / methanol / 6 h / Reflux
4.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -75 °C / Inert atmosphere
4.2: 1 h / -75 - 20 °C
5.1: sodium tetrahydroborate / methanol / 0.5 h / 0 °C
6.1: sodium hydride / tetrahydrofuran; mineral oil / 16.5 h / 20 °C / Cooling with ice
7.1: sodium carbonate / palladium diacetate; 1,1'-bis-(diphenylphosphino)ferrocene / Inert atmosphere
7.2: 50 °C
With
sodium tetrahydroborate; n-butyllithium; sodium azide; sulfuric acid; sodium hydride; sodium carbonate; trifluoroacetic acid; potassium hydroxide; sodium nitrite;
1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate;
In
tetrahydrofuran; methanol; hexane; water; mineral oil;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: hexane / 144 h / 20 °C / Cooling with ice; Darkness
2.1: potassium hydroxide / methanol / 6 h / Reflux
3.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -75 °C / Inert atmosphere
3.2: 1 h / -75 - 20 °C
4.1: sodium tetrahydroborate / methanol / 0.5 h / 0 °C
5.1: sodium hydride / tetrahydrofuran; mineral oil / 16.5 h / 20 °C / Cooling with ice
6.1: sodium carbonate / palladium diacetate; 1,1'-bis-(diphenylphosphino)ferrocene / Inert atmosphere
6.2: 50 °C
With
sodium tetrahydroborate; n-butyllithium; sodium hydride; sodium carbonate; potassium hydroxide;
1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate;
In
tetrahydrofuran; methanol; hexane; mineral oil;
