dimethyl 2-(2-(N,N-bis(2-(trimethylsilyl)ethoxymethyl)sulfamoyl)-1-(4-((2',6'-dimethyl-4'-(3-(methylsulfonyl)propoxy)-[1,1'-biphenyl]-3-yl)methoxy)phenyl)ethyl)malonate

Base Information

Chemical Name:dimethyl 2-(2-(N,N-bis(2-(trimethylsilyl)ethoxymethyl)sulfamoyl)-1-(4-((2',6'-dimethyl-4'-(3-(methylsulfonyl)propoxy)-[1,1'-biphenyl]-3-yl)methoxy)phenyl)ethyl)malonate
CAS No.:1372195-73-7
Molecular Formula:C₄₄H₆₇NO₁₂S₂Si₂
Molecular Weight:922.318
Hs Code.:

dimethyl 2-(2-(N,N-bis(2-(trimethylsilyl)ethoxymethyl)sulfamoyl)-1-(4-((2',6'-dimethyl-4'-(3-(methylsulfonyl)propoxy)-[1,1'-biphenyl]-3-yl)methoxy)phenyl)ethyl)malonate

Synonyms:dimethyl 2-(2-(N,N-bis(2-(trimethylsilyl)ethoxymethyl)sulfamoyl)-1-(4-((2',6'-dimethyl-4'-(3-(methylsulfonyl)propoxy)-[1,1'-biphenyl]-3-yl)methoxy)phenyl)ethyl)malonate

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Chemical Property of dimethyl 2-(2-(N,N-bis(2-(trimethylsilyl)ethoxymethyl)sulfamoyl)-1-(4-((2',6'-dimethyl-4'-(3-(methylsulfonyl)propoxy)-[1,1'-biphenyl]-3-yl)methoxy)phenyl)ethyl)malonate

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Technology Process of dimethyl 2-(2-(N,N-bis(2-(trimethylsilyl)ethoxymethyl)sulfamoyl)-1-(4-((2',6'-dimethyl-4'-(3-(methylsulfonyl)propoxy)-[1,1'-biphenyl]-3-yl)methoxy)phenyl)ethyl)malonate

There total 6 articles about dimethyl 2-(2-(N,N-bis(2-(trimethylsilyl)ethoxymethyl)sulfamoyl)-1-(4-((2',6'-dimethyl-4'-(3-(methylsulfonyl)propoxy)-[1,1'-biphenyl]-3-yl)methoxy)phenyl)ethyl)malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1372195-72-6
(E)-2-(4-((2',6'-dimethyl-4'-(3-(methylsulfonyl)propoxy)-[1,1'-biphenyl]-3-yl)methoxy)phenyl)-N,N-bis((2-(trimethylsilyl)ethoxy)methyl)ethenesulfonamide

: 108-59-8
malonic acid dimethyl ester

: 1372195-73-7
dimethyl 2-(2-(N,N-bis(2-(trimethylsilyl)ethoxymethyl)sulfamoyl)-1-(4-((2',6'-dimethyl-4'-(3-(methylsulfonyl)propoxy)-[1,1'-biphenyl]-3-yl)methoxy)phenyl)ethyl)malonate

Guidance literature:: malonic acid dimethyl ester; With sodium methylate; In tetrahydrofuran; methanol; at 20 ℃; for 0.166667h;

(E)-2-(4-((2',6'-dimethyl-4'-(3-(methylsulfonyl)propoxy)-[1,1'-biphenyl]-3-yl)methoxy)phenyl)-N,N-bis((2-(trimethylsilyl)ethoxy)methyl)ethenesulfonamide; In tetrahydrofuran; methanol; for 65h; Reflux;

Reference yield:

: 1000413-85-3
(2’,6’-dimethyl-4’-(3-(methylsulfonyl)propoxy)-[1,1‘-biphenyl]-3-yl)methanol

: 1372195-73-7
dimethyl 2-(2-(N,N-bis(2-(trimethylsilyl)ethoxymethyl)sulfamoyl)-1-(4-((2',6'-dimethyl-4'-(3-(methylsulfonyl)propoxy)-[1,1'-biphenyl]-3-yl)methoxy)phenyl)ethyl)malonate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sulfuric acid; hydrogen bromide / 3.5 h / 60 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 80 °C / Inert atmosphere

3.1: lithium hexamethyldisilazane / tetrahydrofuran / Cooling

3.2: Cooling

3.3: 20 °C / Cooling

4.1: sodium methylate / tetrahydrofuran; methanol / 0.17 h / 20 °C

4.2: 65 h / Reflux

With sulfuric acid; hydrogen bromide; sodium methylate; potassium carbonate; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

Reference yield:

: 1372195-70-4
N,N-bis((2-(trimethylsilyl)ethoxy)methyl)methanesulfonamide

: 1372195-73-7
dimethyl 2-(2-(N,N-bis(2-(trimethylsilyl)ethoxymethyl)sulfamoyl)-1-(4-((2',6'-dimethyl-4'-(3-(methylsulfonyl)propoxy)-[1,1'-biphenyl]-3-yl)methoxy)phenyl)ethyl)malonate

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / Cooling

1.2: Cooling

1.3: 20 °C / Cooling

2.1: sodium methylate / tetrahydrofuran; methanol / 0.17 h / 20 °C

2.2: 65 h / Reflux

With sodium methylate; lithium hexamethyldisilazane; In tetrahydrofuran; methanol;