5-CHLORO-1,2-DIHYDRO-4-HYDROXY-1-METHYL-2-OXO-3-QUINOLINE CARBOXYLIC ACID

Base Information

• Chemical Name: 5-CHLORO-1,2-DIHYDRO-4-HYDROXY-1-METHYL-2-OXO-3-QUINOLINE CARBOXYLIC ACID
• CAS No.: 335640-50-1
• Molecular Formula: C11H8 Cl N O4
• Molecular Weight: 253.642
• Hs Code.: 2933790090
• Mol file: 335640-50-1.mol

Synonyms:1,2-Dihydro-4-hydroxy-5-chloro-1-methyl-2-oxoquinoline-3-carboxylicacid; 5-Chloro-1,2-dihydro-4-hydroxy-1-methyl-2-oxoquinoline-3-carboxylic acid

Chemical Property of 5-CHLORO-1,2-DIHYDRO-4-HYDROXY-1-METHYL-2-OXO-3-QUINOLINE CARBOXYLIC ACID

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 294.9-295.1 °C
• Refractive Index: 1.691
• Boiling Point: 396.6°Cat760mmHg
• PKA: 1.16±0.20(Predicted)
• Flash Point: 193.7°C
• PSA: 79.53000
• Density: 1.644g/cm³
• LogP: 1.59570

Purity/Quality:

99% ，98% ^*data from raw suppliers

5-CHLORO-1,2-DIHYDRO-4-HYDROXY-1-METHYL-2-OXO-3-QUINOLINE CARBOXYLIC ACID 98.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-CHLORO-1,2-DIHYDRO-4-HYDROXY-1-METHYL-2-OXO-3-QUINOLINE CARBOXYLIC ACID

There total 2 articles about 5-CHLORO-1,2-DIHYDRO-4-HYDROXY-1-METHYL-2-OXO-3-QUINOLINE CARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanol (67-56-1) + laquinimod (248281-84-7) → 5-chloro-1,2-dihydro-4-hydroxy-1-methyl-2-oxoquinoline + 1,2-dihydro-4-hydroxy-5-chloro-1-methyl-2-oxo-quinoline-3-carboxylic acid methyl ester (637027-41-9) + 5-chloro-1,2-dihydro-4-hydroxy-1-methyl-2-oxo-3-quinolinecarboxylic acid (335640-50-1)

Guidance literature:

With water; trifluoroacetic acid; In dimethyl sulfoxide; acetonitrile; at 50 ℃; for 2h; Kinetics;

DOI:10.1021/jo052368q

Reference yield:

ethanol (64-17-5) + laquinimod (248281-84-7) → 5-chloro-1,2-dihydro-4-hydroxy-1-methyl-2-oxoquinoline + 5-chloro-1,2-dihydro-4-hydroxy-1-methyl-2-oxo-3-quinolinecarboxylic acid (335640-50-1) + 5-chloro-1,2-dihydro-4-hydroxy-1-methyl-2-oxo-3-quinolinecarboxylic acid ethyl ester (248282-10-2)

Guidance literature:

With water; trifluoroacetic acid; In dimethyl sulfoxide; acetonitrile; at 50 ℃; for 2h; Further Variations:; Reagents; Kinetics;

DOI:10.1021/jo052368q

Reference yield: 87.0%

N-ethyl-N-phenylamine (103-69-5) + 5-chloro-1,2-dihydro-4-hydroxy-1-methyl-2-oxo-3-quinolinecarboxylic acid (335640-50-1) → laquinimod (248281-84-7)

Guidance literature:

With thionyl chloride; triethylamine; In dichloromethane; at 0 - 20 ℃; for 4.5h;

DOI:10.1021/jm031044w

upstream raw materials:

methanol

laquinimod

ethanol

Downstream raw materials:

laquinimod

N-ethyl-N-D₅-phenyl-1,2-dihydro-4-hydroxy-5-chloro-1-methyl-2-oxoquinoline-3-carboxamide

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