Carbamic acid, (2-amino-1,1-dimethylethyl)-, 1,1-dimethylethyl ester (9CI)

Base Information

• Chemical Name: Carbamic acid, (2-amino-1,1-dimethylethyl)-, 1,1-dimethylethyl ester (9CI)
• CAS No.: 320581-09-7
• Molecular Formula: C9H20 N2 O2
• Molecular Weight: 188.27
• Hs Code.: 2924199090
• Mol file: 320581-09-7.mol

Synonyms:Carbamicacid, (2-amino-1,1-dimethylethyl)-, 1,1-dimethylethyl ester (9CI);(2-Amino-1,1-dimethylethyl)carbamic acid tert-butyl ester

Chemical Property of Carbamic acid, (2-amino-1,1-dimethylethyl)-, 1,1-dimethylethyl ester (9CI)

Chemical Property:

• Boiling Point: 275℃
• PKA: 12.74±0.46(Predicted)
• Flash Point: 120℃
• PSA: 67.84000
• Density: 0.974
• LogP: 2.15310
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

97% ^*data from raw suppliers

tert-butylN-(1-amino-2-methylpropan-2-yl)carbamate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Carbamic acid, (2-amino-1,1-dimethylethyl)-, 1,1-dimethylethyl ester (9CI)

There total 7 articles about Carbamic acid, (2-amino-1,1-dimethylethyl)-, 1,1-dimethylethyl ester (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-tert-Butyloxycarbonylamino-2-methylpropiononitrile → (2-amino-1,1-dimethyl-ethyl)-carbamic acid tert-butyl ester (320581-09-7)

Guidance literature:

2-tert-Butyloxycarbonylamino-2-methylpropiononitrile; With lithium aluminium tetrahydride; In tetrahydrofuran; at -10 ℃;

With water; ammonium chloride; In tetrahydrofuran; ethyl acetate;

DOI:10.1016/j.tet.2010.06.082

Reference yield:

tert-butyl (1-amino-2-methyl-1-oxopropan-2-yl)carbamate (73470-46-9) → (2-amino-1,1-dimethyl-ethyl)-carbamic acid tert-butyl ester (320581-09-7)

Guidance literature:

With diborane; In tetrahydrofuran; at 0 - 20 ℃;

Reference yield:

(2-benzyloxycarbonylamino-1,1-dimethyl-ethyl)-carbamic acid tert-butyl ester (169954-67-0) → (2-amino-1,1-dimethyl-ethyl)-carbamic acid tert-butyl ester (320581-09-7)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 0.5h;

DOI:10.1021/ol201247x

upstream raw materials:

(2-benzyloxycarbonylamino-1,1-dimethyl-ethyl)-carbamic acid tert-butyl ester

C₁₇H₂₂N₂O₄

di-tert-butyl dicarbonate

2-((tert-butyloxycarbonyl)amino)-2-methylpropan-1-ol

Downstream raw materials:

tert-butyl N-{2-[4-chloro-5-cyano-6-(3,5-dimethoxyphenylamino)pyrimidin-2-ylamino]-1,1-dimethylethyl}carbamate

(2-benzyloxycarbonylamino-1,1-dimethyl-ethyl)-carbamic acid tert-butyl ester

C₃₀H₄₁BrN₄O₃

methyl 2-[({2-[(tert-butoxy)carbonylamino]-2-methylpropyl}amino)methyl]-4-(2-chlorophenyl)-5-cyano-6-methyl-1,4-dihydropyridine-3-carboxylate

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