TRANS-2 3-DIPHENYL-1-PROPYLAZIRIDINE

Base Information

• Chemical Name: TRANS-2 3-DIPHENYL-1-PROPYLAZIRIDINE
• CAS No.: 307310-77-6
• Molecular Formula: C₁₇H₁₉N
• Molecular Weight: 237.345
• Mol file: 307310-77-6.mol

Synonyms:trans-2,3-Diphenyl-1-propylaziridine;trans-N-Propyl-2,3-diphenylaziridine

Chemical Property of TRANS-2 3-DIPHENYL-1-PROPYLAZIRIDINE

Chemical Property:

• Vapor Pressure: 0.00024mmHg at 25°C
• Refractive Index: n20/D 1.56(lit.)
• Boiling Point: 324.8°Cat760mmHg
• PKA: 6.10±0.60(Predicted)
• Flash Point: 136.5°C
• PSA: 3.01000
• Density: 1.046g/cm³
• LogP: 4.13250

Purity/Quality:

Safty Information:

• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-27-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of TRANS-2 3-DIPHENYL-1-PROPYLAZIRIDINE

There total 6 articles about TRANS-2 3-DIPHENYL-1-PROPYLAZIRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

propylamine (107-10-8,42939-71-9) + (4R,5R-4,5-diphenyl-(1,3,2)-dioxathiolane-(2,2)-dioxide) (125134-03-4) → (S,S)-N-propyl-2,3-diphenylaziridine (1020745-28-1,307310-77-6)

Guidance literature:

propylamine; (4R,5R-4,5-diphenyl-(1,3,2)-dioxathiolane-(2,2)-dioxide);

With n-butyllithium; optical yield given as %ee;

DOI:10.1002/chem.201002172

Reference yield: 70.0%

(+/-)-(2R,3R)-2-(2-bromophenyl)-3-phenyl-1-propylaziridine + methyl iodide (74-88-4) → (+/-)-(2R,3R)-2-(2-methylphenyl)-3-phenyl-1-propylaziridine + trans-N-propyl-2,3-diphenylaziridine (307310-77-6)

Guidance literature:

(+/-)-(2R,3R)-2-(2-bromophenyl)-3-phenyl-1-propylaziridine; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 1h;

methyl iodide; In tetrahydrofuran; at -78 - 20 ℃; Reagent/catalyst; Time; Reactivity;

DOI:10.1021/jo8016549

Reference yield:

benzylidene dibromide (618-31-5) + N-benzylidenepropylamine (6852-55-7) → N,N'-di(1-methylethyl)-1,2-diphenyl-1,2-ethanediamine (102599-97-3) + (2R,3S)-2,3-Diphenyl-1-propyl-aziridine + trans-N-propyl-2,3-diphenylaziridine (307310-77-6) + 2,4,5-triphenyl-1,3-dipropyl-imidazolidine

Guidance literature:

With magnesium; In diethyl ether; Further byproducts given; Irradiation;

DOI:10.1016/S0040-4039(01)00271-4

upstream raw materials:

propylamine

2,3-diphenyloxirane

benzylidene dibromide

N-benzylidenepropylamine