6852-55-7

Basic information

• Product Name: N-Propylbenzylideneamine
• Synonyms: N-(Phenylmethylene)-1-propanamine;N-Benzylidene-1-propanamine;N-Benzylidenepropylamine;N-Propylbenzenemethanimine;N-Propylbenzylideneamine
• CAS NO: 6852-55-7
• Molecular Formula: C₁₀H₁₃N
• Molecular Weight: 147.2169
• Mol File: 6852-55-7.mol
• Article Data: 53

Chemical Properties

• Boiling Point: 225.1°Cat760mmHg
• Flash Point: 81.5°C
• Appearance: /
• Density: 0.87g/cm³
• Vapor Pressure: 0.131mmHg at 25°C
• Refractive Index: 1.492
• CAS DataBase Reference: N-Propylbenzylideneamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-Propylbenzylideneamine(6852-55-7)
• EPA Substance Registry System: N-Propylbenzylideneamine(6852-55-7)

Safety Data

• Hazardous Substances Data: 6852-55-7(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H13N/c1-2-8-11-9-10-6-4-3-5-7-10/h3-7,9H,2,8H2,1H3/b11-9+

Upstream product

• 107-10-8 propylamine 
• 538-51-2 benzylidene phenylamine 
• 143-33-9 sodium cyanide 
• 100-52-7 benzaldehyde 
• 4460-46-2 3-chloro-3-phenyl-3H-diazirine 
• 100-51-6 benzyl alcohol 
• 53431-72-4 α-nitro cinnamate de methyle 
• 75-31-0 isopropylamine 
• 100-44-7 benzyl chloride 
• 15241-23-3 (Z)-nitrostyrene 
• 5153-67-3 nitrostyrene 
• 100-46-9 benzylamine 
• 765312-46-7 2-(3',5'-dimethylphenyl)-1-pyrroline 
• 556-96-7 5-bromo-1,3-xylene 

Downstream Products

• 35331-78-3 N-Propyl-N-(α-chlorobenzyl)carbamoylchlorid 
• 20193-20-8 ethylpropylamine 
• 96413-49-9 4-phenyl-4-(n-propylamino)-3-(trimethylsilyl)-1,2-butadiene 
• 226723-82-6 (1-Phenyl-but-3-enyl)-propyl-amine 
• 6852-58-0 N-benzylidene tert-butylamine 
• 102599-97-3 N,N'-di(1-methylethyl)-1,2-diphenyl-1,2-ethanediamine 
• 307310-77-6 trans-N-propyl-2,3-diphenylaziridine 
• 157047-34-2 (C₅H₅)Ti(SCH(C₆H₅CHNC₃H₇)CH₂CH₂S) 
• 210413-23-3 Pd(CH₃)(N(C₃H₇)CHC₆H₅)(C₃₀H₂₄P₂)⁽¹⁺⁾*BF₄^(1-) = [Pd(CH₃)(N(C₃H₇)CHC₆H₅)(C₃₀H₂₄P₂)]BF₄ 

Relevant articles and documents

Design, synthesis, and antiviral evaluation of purine-β-lactam and purine-aminopropanol hybrids

Purine-β-lactam chimera were prepared as a novel class of hybrid systems through N-alkylation of 6-benzylamino- or 6-benzyloxypurine with (ω-haloalkyl)-β-lactams, followed by reductive ring opening of the β-lactam ring by LiEt3BH to provide an entry into the class of purine-aminopropanol hybrids. Both new types of hybrid systems were assessed for their antiviral activity and cytotoxicity, resulting in the identification of eight purine-β-lactam hybrids and two purine-aminopropanol hybrids as promising lead structures.

Discovery of tert-amine-based RORγt agonists

The nuclear receptor retinoic acid receptor-related orphan receptor gamma-t (RORγt) is a transcription factor regulating Th17 cell differentiation and proliferation from naive CD4+ T cells. Since Th17 cells have demonstrated the antitumor efficacy by eliciting remarkable activation of CD8+ T cells, RORγt agonists could be applied as potential small molecule therapeutics for cancer immunotherapy. Based on the previously reported RORγt agonist 1 and its resolved co-crystal structure, a series of new tertiary amines were designed, synthesized and biologically evaluated, yielding optimal moieties with improved chemical properties and biological responses. The combination of these optimal moieties resulted in identification of novel RORγt agonists such as 8b with further elevated RORγt agonism responses at a target-based level as well as in cell-based assays, which provided some structural knowledge for further optimization of RORγt agonists as small molecule therapeutics for cancer immunotherapy.

Efficient Co-Catalyzed Double Hydroboration of Nitriles: Application to One-Pot Conversion of Nitriles to Aldimines

The commercially available and bench-stable Co(acac)2/dpephos system is employed as a precatalyst for selective and efficient room temperature hydroboration of organic nitriles with HBPin to produce a series of N,N-diborylamines [RN(BPin)2], which react in situ with aldehydes to give aldimines. Formation of aldimines from N,N-diborylamines does not require a dehydrating agent, is applicable to a wide range of N,N-diborylamine and aldehyde substrates and is highly chemoselective, being unaffected by various common functional groups, such as alkenes, alkynes, secondary amines, ketones, esters, amides, carboxylic acids, pyridines, nitriles, and nitro compounds. The overall transformation represents a synthetically valuable approach to aldimines from nitriles and can be performed in a sequential one-pot manner, tolerating ester, lactone, carboxamide and unactivated alkene functionalities.