[1-(4-Methoxy-phenyl)-meth-(E)-ylidene]-phosphoramidic acid diethyl ester

Base Information

• Chemical Name: [1-(4-Methoxy-phenyl)-meth-(E)-ylidene]-phosphoramidic acid diethyl ester
• CAS No.: 180399-97-7
• Molecular Formula: C₁₂H₁₈NO₄P
• Molecular Weight: 271.253
• Mol file: 180399-97-7.mol

Synonyms:[1-(4-Methoxy-phenyl)-meth-(E)-ylidene]-phosphoramidic acid diethyl ester

Chemical Property of [1-(4-Methoxy-phenyl)-meth-(E)-ylidene]-phosphoramidic acid diethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [1-(4-Methoxy-phenyl)-meth-(E)-ylidene]-phosphoramidic acid diethyl ester

There total 2 articles about [1-(4-Methoxy-phenyl)-meth-(E)-ylidene]-phosphoramidic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

4-methoxybenzaldehyde diethylacetal (2403-58-9) + Diethyl phosphoramidate (1068-21-9) → [1-(4-Methoxy-phenyl)-meth-(E)-ylidene]-phosphoramidic acid diethyl ester (180399-97-7)

Guidance literature:

for 0.75h; Heating;

DOI:10.1016/0040-4020(96)00420-6

Reference yield:

4-methoxy-benzaldehyde (123-11-5) → [1-(4-Methoxy-phenyl)-meth-(E)-ylidene]-phosphoramidic acid diethyl ester (180399-97-7)

Guidance literature:

Multi-step reaction with 2 steps

1: triethyl orthoformate, ammonium chloride / 0.75 h / Heating

2: 82 percent / 0.75 h / Heating

With ammonium chloride; orthoformic acid triethyl ester;

DOI:10.1016/0040-4020(96)00420-6

Reference yield: 62.0%

danishefsky's diene (54125-02-9) + [1-(4-Methoxy-phenyl)-meth-(E)-ylidene]-phosphoramidic acid diethyl ester (180399-97-7) → [2-(4-methoxy-phenyl)-4-oxo-3,4-dihydro-2H-pyridin-1-yl]-phosphonic acid diethyl ester

Guidance literature:

With copper(II) bis(trifluoromethanesulfonate); In dichloromethane; at 20 ℃;

DOI:10.1055/s-2004-817742

upstream raw materials:

4-methoxybenzaldehyde diethylacetal

Diethyl phosphoramidate

4-methoxy-benzaldehyde

Downstream raw materials:

[1-(4-methoxy-phenyl)-pentyl]-phosphoramidic acid diethyl ester

1-(4-methoxyphenyl)propan-1-amine hydrochloride

4-methoxy-benzhydrylamine; hydrochloride