6-((1s,4s)-4-aminocyclohexyl)-2-(phenylamino)-N-(2-(piperidin-1-yl)ethyl)nicotinamide

Base Information

Chemical Name:6-((1s,4s)-4-aminocyclohexyl)-2-(phenylamino)-N-(2-(piperidin-1-yl)ethyl)nicotinamide
CAS No.:1246610-01-4
Molecular Formula:C₂₅H₃₅N₅O
Molecular Weight:421.586
Hs Code.:

Synonyms:6-((1s,4s)-4-aminocyclohexyl)-2-(phenylamino)-N-(2-(piperidin-1-yl)ethyl)nicotinamide

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Chemical Property of 6-((1s,4s)-4-aminocyclohexyl)-2-(phenylamino)-N-(2-(piperidin-1-yl)ethyl)nicotinamide

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Technology Process of 6-((1s,4s)-4-aminocyclohexyl)-2-(phenylamino)-N-(2-(piperidin-1-yl)ethyl)nicotinamide

There total 7 articles about 6-((1s,4s)-4-aminocyclohexyl)-2-(phenylamino)-N-(2-(piperidin-1-yl)ethyl)nicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1246610-00-3
tert-butyl (1s,4s)-4-(6-(phenylamino)-5-(2-(piperidin-1-yl)ethylcarbamoyl)pyridin-2-yl)cyclohexylcarbamate

: 1246610-01-4
6-((1s,4s)-4-aminocyclohexyl)-2-(phenylamino)-N-(2-(piperidin-1-yl)ethyl)nicotinamide

Guidance literature:: tert-butyl (1s,4s)-4-(6-(phenylamino)-5-(2-(piperidin-1-yl)ethylcarbamoyl)pyridin-2-yl)cyclohexylcarbamate; With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 20 ℃; for 4h;

With sodium carbonate; In dichloromethane;

Reference yield:

: 53292-90-3
cis-4-tert-butoxycarbonylaminocyclohexane-1-ylcarboxylic acid

: 1246610-01-4
6-((1s,4s)-4-aminocyclohexyl)-2-(phenylamino)-N-(2-(piperidin-1-yl)ethyl)nicotinamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / tetrahydrofuran / 48 h / 20 °C

2.1: ethyl acetate; tetrahydrofuran / 4 h / 0 °C

2.2: Cooling with ice

3.1: ethanol / 24 h / Reflux

4.1: sodium hydroxide; ethanol / 2 h / 20 °C

4.2: pH 5

5.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / tetrahydrofuran / 24 h / 20 °C

6.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 4 h / 20 °C

With hydrogenchloride; ethanol; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; ethyl acetate; 3.1: Bohlman-Rahtz Reaction;

Reference yield:

: 304873-79-8
tert-butyl ((1s,4s)-4-(methoxy(methyl)carbamoyl)cyclohexyl)carbamate

: 1246610-01-4
6-((1s,4s)-4-aminocyclohexyl)-2-(phenylamino)-N-(2-(piperidin-1-yl)ethyl)nicotinamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: ethyl acetate; tetrahydrofuran / 4 h / 0 °C

1.2: Cooling with ice

2.1: ethanol / 24 h / Reflux

3.1: sodium hydroxide; ethanol / 2 h / 20 °C

3.2: pH 5

4.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / tetrahydrofuran / 24 h / 20 °C

5.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 4 h / 20 °C

With hydrogenchloride; ethanol; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; ethyl acetate; 2.1: Bohlman-Rahtz Reaction;