3-bromo-6-methyl-6-(3-nitrophenyl)-6,7-dihydropyrazolo[1,5-a]pyrazin-4-amine

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Chemical Name:3-bromo-6-methyl-6-(3-nitrophenyl)-6,7-dihydropyrazolo[1,5-a]pyrazin-4-amine
CAS No.:1397683-45-2
Molecular Formula:C₁₃H₁₂BrN₅O₂
Molecular Weight:350.175
Hs Code.:

Synonyms:3-bromo-6-methyl-6-(3-nitrophenyl)-6,7-dihydropyrazolo[1,5-a]pyrazin-4-amine

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Chemical Property of 3-bromo-6-methyl-6-(3-nitrophenyl)-6,7-dihydropyrazolo[1,5-a]pyrazin-4-amine

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Technology Process of 3-bromo-6-methyl-6-(3-nitrophenyl)-6,7-dihydropyrazolo[1,5-a]pyrazin-4-amine

There total 9 articles about 3-bromo-6-methyl-6-(3-nitrophenyl)-6,7-dihydropyrazolo[1,5-a]pyrazin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 3.0%

: 1397683-43-0
3-bromo-6-methyl-6-(3-nitrophenyl)-6,7-dihydropyrazolo[1,5-a]pyrazine-4(5H)-thione

: 1397683-44-1
6-(3-aminophenyl)-6-methyl-6,7-dihydropyrazolo[1,5-a]pyrazin-4-amine

: 1397683-45-2
3-bromo-6-methyl-6-(3-nitrophenyl)-6,7-dihydropyrazolo[1,5-a]pyrazin-4-amine

Guidance literature:: With ammonia; In methanol; water; at 100 ℃; for 6h; Sealed tube;

Reference yield:

: 1397683-33-8
tert-butyl 4-methyl-4-(3-nitrophenyl)-1,2,3-oxathiazolidine-3-carboxylate-2,2-dioxide

: 1397683-45-2
3-bromo-6-methyl-6-(3-nitrophenyl)-6,7-dihydropyrazolo[1,5-a]pyrazin-4-amine

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium carbonate / N,N-dimethyl-formamide / 2 h / 130 °C

2.1: lithium diisopropyl amide / tetrahydrofuran; cyclohexane; ethylbenzene / 1 h / -78 °C

2.2: 1 h / -78 - -50 °C

3.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

4.1: potassium acetate / ethanol / 4 h / Reflux

5.1: tetraphosphorus decasulfide; pyridine / 24 h / 110 °C

6.1: ammonia / methanol / 100 °C

With pyridine; tetraphosphorus decasulfide; ammonia; potassium acetate; sodium carbonate; trifluoroacetic acid; lithium diisopropyl amide; In tetrahydrofuran; methanol; ethanol; dichloromethane; cyclohexane; ethylbenzene; N,N-dimethyl-formamide;
DOI:10.1021/acsmedchemlett.9b00181

Reference yield:

: 1397683-47-4
ethyl 4-bromo-1-(2-((tert-butoxycarbonyl)amino)-2-(3-nitrophenyl)propyl)-1H-pyrazole-5-carboxylate

: 1397683-45-2
3-bromo-6-methyl-6-(3-nitrophenyl)-6,7-dihydropyrazolo[1,5-a]pyrazin-4-amine

Guidance literature:: Multi-step reaction with 4 steps

1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

2: potassium acetate / ethanol / 4 h / Reflux

3: tetraphosphorus decasulfide; pyridine / 24 h / 110 °C

4: ammonia / methanol / 100 °C

With pyridine; tetraphosphorus decasulfide; ammonia; potassium acetate; trifluoroacetic acid; In methanol; ethanol; dichloromethane;
DOI:10.1021/acsmedchemlett.9b00181