ethyl 2-phenyl-5-(prop-2'-en-1'-yl)-1-pyrroline-5-carboxylate 1-oxide

Base Information

• Chemical Name: ethyl 2-phenyl-5-(prop-2'-en-1'-yl)-1-pyrroline-5-carboxylate 1-oxide
• CAS No.: 212263-60-0
• Molecular Formula: C₁₆H₁₉NO₃
• Molecular Weight: 273.332
• Mol file: 212263-60-0.mol

Synonyms:ethyl 2-phenyl-5-(prop-2'-en-1'-yl)-1-pyrroline-5-carboxylate 1-oxide

Chemical Property of ethyl 2-phenyl-5-(prop-2'-en-1'-yl)-1-pyrroline-5-carboxylate 1-oxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-phenyl-5-(prop-2'-en-1'-yl)-1-pyrroline-5-carboxylate 1-oxide

There total 6 articles about ethyl 2-phenyl-5-(prop-2'-en-1'-yl)-1-pyrroline-5-carboxylate 1-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

ethyl 2-phenyl-1-pyrroline-5-carboxylate 1-oxide (212265-33-3) → ethyl 2-phenyl-5-(prop-2'-en-1'-yl)-1-pyrroline-5-carboxylate 1-oxide (212263-60-0)

Guidance literature:

ethyl 2-phenyl-1-pyrroline-5-carboxylate 1-oxide; With sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 0.0833333h;

CH₂=CHCH₂X, X = halide; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1055/s-2006-942380

Reference yield: 66.0%

3-chloroprop-1-ene (107-05-1) + ethyl 2-phenyl-1-pyrroline-5-carboxylate 1-oxide (212265-33-3) → ethyl 2-phenyl-5-(prop-2'-en-1'-yl)-1-pyrroline-5-carboxylate 1-oxide (212263-60-0)

Guidance literature:

ethyl 2-phenyl-1-pyrroline-5-carboxylate 1-oxide; With sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃;

3-chloroprop-1-ene; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1016/S0040-4020(00)00094-6

Reference yield:

3-diethylamino-1-phenyl-propan-1-one (94-38-2) → ethyl 2-phenyl-5-(prop-2'-en-1'-yl)-1-pyrroline-5-carboxylate 1-oxide (212263-60-0)

Guidance literature:

Multi-step reaction with 5 steps

1.1: 100 percent / toluene / Heating

2.1: 92 percent / Zn; NH₄Cl / tetrahydrofuran; H₂O / 10 °C

3.1: 54 percent / H₂ / Pd/C / ethanol / 6 h / 760 Torr

4.1: Na₂WO₄; urea hydrogen peroxide / methanol / 3 h / 20 °C

5.1: NaH / tetrahydrofuran; dimethylformamide / 20 °C

5.2: 66 percent / tetrahydrofuran; dimethylformamide / 20 °C

With sodium tungstate; urea hydrogen peroxide; hydrogen; sodium hydride; ammonium chloride; zinc; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide; toluene; 1.1: Condensation / 2.1: Reduction / 3.1: Reduction / 4.1: Oxidation / 5.1: Metallation / 5.2: Alkylation;

DOI:10.1016/S0040-4020(00)00094-6

upstream raw materials:

3-chloroprop-1-ene

ethyl 2-phenyl-1-pyrroline-5-carboxylate 1-oxide

ethyl 2-nitro-5-oxo-5-phenylpentanoate

3-diethylamino-1-phenyl-propan-1-one