94-38-2

Basic information

• Product Name: 3-(diethylamino)propiophenone
• Synonyms: 3-(diethylamino)propiophenone;3-(diethylamino)-1-phenylpropan-1-one;1-Phenyl-3-(diethylamino)-1-propanone;3-(Diethylamino)-1-phenyl-1-propanone;3-(diethylamino)-1-phenylpropan-1-one HCl
• CAS NO: 94-38-2
• Molecular Formula: C₁₃H₁₉NO
• Molecular Weight: 205.29606
• EINECS: 202-329-7
• Mol File: 94-38-2.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 301.7°C at 760 mmHg
• Flash Point: 101.4°C
• Appearance: /
• Density: 0.974g/cm³
• Vapor Pressure: 0.00103mmHg at 25°C
• Refractive Index: 1.511
• CAS DataBase Reference: 3-(diethylamino)propiophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(diethylamino)propiophenone(94-38-2)
• EPA Substance Registry System: 3-(diethylamino)propiophenone(94-38-2)

Safety Data

• Hazardous Substances Data: 94-38-2(Hazardous Substances Data)

Usage

General Description

3-(diethylamino)propiophenone, also known as DEP, is a chemical compound that belongs to the family of aryl ketones. It is a white to pale yellow crystalline solid with a pungent odor. DEP is commonly used as an intermediate in the production of various pharmaceuticals and as a reagent in organic synthesis. It is also utilized as a precursor in the manufacture of dyes, pigments, and other fine chemicals. Additionally, DEP is known for its potential use as a reagent in the synthesis of biologically active compounds and as a building block in the development of new materials. However, it is important to handle DEP with caution due to its potential hazards, including being harmful if swallowed, inhaled, or in contact with skin, and causing skin and eye irritation.

InChI:InChI=1/C13H19NO/c1-3-14(4-2)11-10-13(15)12-8-6-5-7-9-12/h5-9H,3-4,10-11H2,1-2H3

Upstream product

• 660-68-4 diethyl amine hydrochloride 
• 98-86-2 acetophenone 
• 4187-87-5 1-Phenyl-2-propyn-1-ol 
• 100-52-7 benzaldehyde 
• 14103-77-6 1,3-dimethylimidazolidine 
• 109-89-7 diethylamine 
• 7352-03-6 N-(ethoxymethyl)diethylamine 
• 21440-46-0 1-Phenyl-3-p-toluolsulfonyl-propen-⁽²⁾-on-⁽¹⁾ 
• 3204-31-7 1,3-Dimethyl-2,3-dihydro-1H-benzoimidazole 
• 7664-93-9 sulfuric acid 
• 50-00-0 formaldehyd 
• 768-03-6 Phenyl vinyl ketone 
• 91935-86-3 1-Phenyl-3-p-tolylsulfonyl-2-propen-1-ol 
• 24070-51-7 β-iodopropiophenone 

Downstream Products

• 3506-43-2 4-(3-oxo-3-phenylpropylamino)benzoic acid 
• 62365-91-7 3-(N-3'-Oxo-3'-phenylpropyl)-aminochinolin 
• 109309-44-6 N,N-diethyl-3-phenylbut-3-en-1-amine 
• 14398-97-1 (1-methylpyrrolidin-3-yl)(phenyl)methanone 
• 5409-66-5 3-benzoyl-4-hydroxy-1-methyl-4-phenylpiperidine 
• 745826-58-8 9-(3-oxo-3-phenyl-propyl)-fluorene-9-carboxylic acid 
• 857983-49-4 3-(9H-fluoren-9-yl)-1-phenylpropan-1-one 
• 102700-17-4 6-diethylamino-4,4-diphenyl-hexan-3-one 
• 859060-24-5 diethyl-(3-chloro-3,3-diphenyl-propyl)-amine 
• 5558-76-9 4-diethylamino-2,2-diphenyl-butyronitrile 
• 140697-40-1 cis-2,3-Dimethyl-1-ethyl-3-phenylpyrrolidine 
• 140697-40-1 trans-2,3-Dimethyl-1-ethyl-3-phenylpyrrolidine 
• 583-05-1 1-phenylpentane-1,4-dione 

Relevant articles and documents

Metal-free synthesis of β-aminoketones by the reductive hydroamination of ynones

This study describes a cascade method for the synthesis of β-aminoketones through the reductive hydroamination of alkynes under very mild metal-free conditions. It allows for the rapid conversion of ynones and amines into corresponding β-aminoketones with a broad substrate scope and diverse functionalities. This straightforward and easy-to-handle reaction process can be successfully applied for the synthesis of Proroxan and Propipocaine, offering a potential option for the synthesis of drug molecules with the β-aminoketone skeleton.

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A novel method for biomimetic synthesis of Mannich bases

Since the early studies of Mannich, Mannich reaction has become an important tool for the synthesis of new compounds. Mannich bases can be either directly employed or used as intermediates. In this work, the one-carbon unit transfer reaction of tetrahydrofolate coenzyme was initiated. 1,3-Dimethylimidazolidine as a new tetrahydrofolate coenzyme model at formaldehyde oxidation level was used to react with ketone having active hydrogen atoms and amine to give the corresponding Mannich base in good yield by a covert Mannich reaction. A novel method for biomimetic synthesis of various Mannich bases is provided. 1,3-Dimethylimidazolidine as a new tetrahydrofolate coenzyme model at formaldehyde oxidation level was used to react with ketone having active hydrogen atoms and amine to give the corresponding Mannich base in good yield by a covert Mannich reaction. A novel method for biomimetic synthesis of various Mannich bases is provided. Copyright