212265-33-3

Upstream product

• 952-27-2 5-Ethoxycarbonyl-2-phenyl-Δ¹-pyrroline 
• 94-38-2 3-diethylamino-1-phenyl-propan-1-one 
• 91958-55-3 ethyl 2-nitro-5-oxo-5-phenylpentanoate 
• 952-26-1 ethyl 5-phenylpyrrolidine-2-carboxylate 

Downstream Products

• 212263-60-0 ethyl 2-phenyl-5-(prop-2'-en-1'-yl)-1-pyrroline-5-carboxylate 1-oxide 
• 212263-61-1 ethyl 5-(but-3'-en-1'-yl)-2-phenyl-1-pyrroline-5-carboxylate 1-oxide 
• 212263-62-2 ethyl 5-(pent-4'-en-1'-yl)-2-phenyl-1-pyrroline-5-carboxylate 1-oxide 
• 212263-63-3 ethyl 5-(hex-5'-en-1'-yl)-2-phenyl-1-pyrroline-5-carboxylate 1-oxide 
• 212265-39-9 ethyl 5-(4'-methylpent-3'-en-1'-yl)-2-phenyl-1-pyrroline-5-carboxylate 
• 212265-36-6 ethyl 5-(but-3'-en-1'-yl)-2-phenyl-1-pyrroline-5-carboxylate 
• 212265-34-4 ethyl 5-(4'-methylpent-3'-en-1'-yl)-2-phenyl-1-pyrroline-5-carboxylate 1-oxide 
• 13355-43-6 5-phenyl-1H-pyrrole-2-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

Synthesis and reactivity of 1-pyrroline-5-carboxylate ester 1-oxides

Some C5 mono- and diester-substituted 1-pyrroline-1-oxides have been prepared via reductive cyclisation of the corresponding γ-nitro carbonyl compounds. Ethyl 2-phenyl-1-pyrroline-1-oxide-5-carboxylate 5c was regioselectively alkylated at C5. Acylation of this molecule occurs exclusively on the nitrone oxygen and leads to C3 substituted pyrrolines as the result of a hetero-Cope rearrangement. (C) 2000 Elsevier Science Ltd.