4-(6,7-Dimethoxyquinolin-4-yloxy)phenylcarbamic acid phenyl ester

Base Information

• Chemical Name: 4-(6,7-Dimethoxyquinolin-4-yloxy)phenylcarbamic acid phenyl ester
• CAS No.: 347151-53-5
• Molecular Formula: C₂₄H₂₀N₂O₅
• Molecular Weight: 416.433
• Mol file: 347151-53-5.mol

Synonyms:4-(6,7-Dimethoxyquinolin-4-yloxy)phenylcarbamic acid phenyl ester

Chemical Property of 4-(6,7-Dimethoxyquinolin-4-yloxy)phenylcarbamic acid phenyl ester

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 4-(6,7-Dimethoxyquinolin-4-yloxy)phenylcarbamic acid phenyl ester

There total 15 articles about 4-(6,7-Dimethoxyquinolin-4-yloxy)phenylcarbamic acid phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

4-((6,7-dimethoxyquinolin-4-yl)oxy)aniline (190728-25-7) + bis(trichloromethyl) carbonate (32315-10-9) + sodium hydrogencarbonate (144-55-8) + phenol (108-95-2,27073-41-2) → 4-(6,7-Dimethoxyquinolin-4-yloxy)phenylcarbamic acid phenyl ester (347151-53-5)

Guidance literature:

With triethylamine; In methanol; dichloromethane; chloroform; toluene;

Reference yield: 63.0%

4-((6,7-dimethoxyquinolin-4-yl)oxy)aniline (190728-25-7) + bis(trichloromethyl) carbonate (32315-10-9) + phenol (108-95-2,27073-41-2) → 4-(6,7-Dimethoxyquinolin-4-yloxy)phenylcarbamic acid phenyl ester (347151-53-5)

Guidance literature:

4-((6,7-dimethoxyquinolin-4-yl)oxy)aniline; bis(trichloromethyl) carbonate; With triethylamine; In dichloromethane; toluene; for 0.166667h; Heating;

phenol; In dichloromethane; toluene; for 3h; Heating;

DOI:10.1021/jm0506423

Reference yield:

4-((6,7-dimethoxyquinolin-4-yl)oxy)aniline (190728-25-7) + phenyl chloroformate (1885-14-9) → 4-(6,7-Dimethoxyquinolin-4-yloxy)phenylcarbamic acid phenyl ester (347151-53-5)

Guidance literature:

With pyridine; In dichloromethane; for 2h;

DOI:10.1016/j.bmcl.2019.126630

upstream raw materials:

4-((6,7-dimethoxyquinolin-4-yl)oxy)aniline

bis(trichloromethyl) carbonate

phenol

6,7-dimethoxy-4-chloroquinoline

Downstream raw materials:

N-Cyclopropyl-N'-(4-(6,7-dimethoxyquinolin-4-yloxy)phenyl)urea

N-(thiazol-2-yl)-N'-(4-((6,7-dimethoxy-4-quinolinyl)oxy)phenyl)urea