(+/-)-phenyl (8-methyl-5-(4-nitrophenyl)-8,9-dihydro-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine-3-carbothioyl)-carbamate

Base Information

Chemical Name:(+/-)-phenyl (8-methyl-5-(4-nitrophenyl)-8,9-dihydro-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine-3-carbothioyl)-carbamate
CAS No.:732277-00-8
Molecular Formula:C₂₅H₂₀N₄O₆S
Molecular Weight:504.523
Hs Code.:

Synonyms:(+/-)-phenyl (8-methyl-5-(4-nitrophenyl)-8,9-dihydro-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine-3-carbothioyl)-carbamate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (+/-)-phenyl (8-methyl-5-(4-nitrophenyl)-8,9-dihydro-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine-3-carbothioyl)-carbamate

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Technology Process of (+/-)-phenyl (8-methyl-5-(4-nitrophenyl)-8,9-dihydro-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine-3-carbothioyl)-carbamate

There total 1 articles about (+/-)-phenyl (8-methyl-5-(4-nitrophenyl)-8,9-dihydro-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine-3-carbothioyl)-carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 143692-49-3,161832-62-8,161832-63-9
1-(4-Nitrophenyl)-4-methyl-7,8-methylenedioxy-3,4-dihydro-5H-2,3-benzodiazepine

: 333-20-0
potassium thioacyanate

: 1885-14-9
phenyl chloroformate

: 732277-00-8
(+/-)-phenyl (8-methyl-5-(4-nitrophenyl)-8,9-dihydro-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine-3-carbothioyl)-carbamate

Guidance literature:: potassium thioacyanate; phenyl chloroformate; In acetone; at 20 - 40 ℃; for 0.75h;

1-(4-Nitrophenyl)-4-methyl-7,8-methylenedioxy-3,4-dihydro-5H-2,3-benzodiazepine; In acetone; at 0 ℃; for 1h;

Reference yield: 73.0%

: 732277-00-8
(+/-)-phenyl (8-methyl-5-(4-nitrophenyl)-8,9-dihydro-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine-3-carbothioyl)-carbamate

: 74-89-5
methylamine

: 732277-01-9
(+/-)-1-Methyl-3-{8-methyl-5-(4-nitrophenyl)-8,9-dihydro-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine-7-carbothioyl}-urea

Guidance literature:: In DMF (N,N-dimethyl-formamide); water; for 2h;

Reference yield:

: 732277-00-8
(+/-)-phenyl (8-methyl-5-(4-nitrophenyl)-8,9-dihydro-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine-3-carbothioyl)-carbamate

: 732277-58-6
(+/-)-8-Methyl-7-(2-methyl-3-oxo-2,3-dihydro-1,2,4-thiadiazol-5-yl)-5-(4-nitrophenyl)-8,9-dihydro-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine

Guidance literature:: Multi-step reaction with 2 steps

1: DMF (N,N-dimethyl-formamide); water / 2 h

2: bromine / chloroform / 0.5 h / 0 °C

With bromine; In DMF (N,N-dimethyl-formamide); chloroform; water;