N-(4-CHLORO-2-PYRIDINYL)-ACETAMIDE

Base Information

• Chemical Name: N-(4-CHLORO-2-PYRIDINYL)-ACETAMIDE
• CAS No.: 245056-66-0
• Molecular Formula: C₇H₇ClN₂O
• Molecular Weight: 170.598
• Hs Code.: 29333990
• Mol file: 245056-66-0.mol

Synonyms:N-(4-Chloro-2-pyridyl)acetamide;

Chemical Property of N-(4-CHLORO-2-PYRIDINYL)-ACETAMIDE

Chemical Property:

• Vapor Pressure: 3.01E-05mmHg at 25°C
• Refractive Index: 1.597
• Boiling Point: 356 °C at 760 mmHg
• Flash Point: 169.1 °C
• PSA: 41.99000
• Density: 1.336 g/cm³
• LogP: 1.76640
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

N-(4-Chloropyridin-2-yl)acetamide ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(4-CHLORO-2-PYRIDINYL)-ACETAMIDE

There total 3 articles about N-(4-CHLORO-2-PYRIDINYL)-ACETAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-Amino-4-chloropyridine (19798-80-2) + acetic anhydride (108-24-7) → N-(4-chloropyridin-2-yl)acetamide (245056-66-0)

Guidance literature:

With triethylamine; at 20 - 60 ℃; for 12h;

Reference yield: 83.0%

2-Amino-4-chloropyridine (19798-80-2) + acetyl chloride (75-36-5) → N-(4-chloropyridin-2-yl)acetamide (245056-66-0)

Guidance literature:

With pyridine; at 0 ℃; for 1h; Inert atmosphere;

DOI:10.1039/c6md00039h

Reference yield: 82.0%

acetamide (60-35-5) + 2,4-dichloropyridine (26452-80-2) → N-(4-chloropyridin-2-yl)acetamide (245056-66-0)

Guidance literature:

With 1,1'-bis-(diphenylphosphino)ferrocene; potassium phosphate; palladium diacetate; In 1,4-dioxane; at 90 ℃; for 22h; Inert atmosphere; Sealed tube;

DOI:10.1021/acs.orglett.8b01483

upstream raw materials:

2-Amino-4-chloropyridine

acetic anhydride

acetyl chloride

acetamide

Downstream raw materials:

tert-butyl 4-(4-((4-((6-ethoxy-1-(methylcarbamoyl)-1H-indol-5-yl)oxy)pyridin-2-yl) carbamoyl)phenyl)piperidine-1-carboxylate

N-(4-(4-amino-2-fluorophenoxy)pyridin-2-yl)acetamide

tert-butyl 3-fluoro-4-(4-((4-((6-methoxy-1-(methylcarbamoyl)-1H-indol-5-yl)oxy)pyridin-2-yl)carbamoyl)phenyl)piperidine-1-carboxylate

tert-butyl 4-(4-((4-((6-methoxy-1-(methylcarbamoyl)-1H-indol-5-yl)oxy)pyridin-2-yl)carbamoyl)phenyl)piperidine-1-carboxylate

Refernces

• 1、 Liu, Ju,Liu, Fang,Li, Zhen,Li, Chunyan,Wu, Shuang,Shen, Jiwei,Wang, Huan,Du, Siyuan,Wei, Hao,Hou, Yunlei,Ding, Shi,Chen, Ye. "Novel 4-phenoxypyridine derivatives bearing imidazole-4-carboxamide and 1,2,4-triazole-3-carboxamide moieties: Design, synthesis and biological evaluation as potent antitumor agents". . . Retrieved 2022/01/26.
• 2、 Zhang, Hefeng,Peng, Xia,Dai, Yang,Shao, Jingwei,Ji, Yinchun,Sun, Yiming,Liu, Bo,Cheng, Xu,Ai, Jing,Duan, Wenhu. "Discovery of a Pyrimidinedione Derivative as a Potent and Orally Bioavailable Axl Inhibitor". . p. 3956 - 3975. Retrieved 2021/04/12.