Tert-butyl 4-({4-oxo-3-[4-(2,2,2-trifluoroethoxy)phenyl]-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-2-yl}sulfanyl)butanoate

Base Information

• Chemical Name: Tert-butyl 4-({4-oxo-3-[4-(2,2,2-trifluoroethoxy)phenyl]-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-2-yl}sulfanyl)butanoate
• CAS No.: 1236766-41-8
• Molecular Formula: C₂₂H₂₄F₃N₃O₄S
• Molecular Weight: 483.511

Synonyms:Tert-butyl 4-({4-oxo-3-[4-(2,2,2-trifluoroethoxy)phenyl]-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-2-yl}sulfanyl)butanoate

Chemical Property of Tert-butyl 4-({4-oxo-3-[4-(2,2,2-trifluoroethoxy)phenyl]-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-2-yl}sulfanyl)butanoate

Chemical Property:

Purity/Quality:

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Technology Process of Tert-butyl 4-({4-oxo-3-[4-(2,2,2-trifluoroethoxy)phenyl]-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-2-yl}sulfanyl)butanoate

There total 1 articles about Tert-butyl 4-({4-oxo-3-[4-(2,2,2-trifluoroethoxy)phenyl]-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-2-yl}sulfanyl)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-thioxo-3-[4-(2,2,2-trifluoroethoxy)phenyl]-1,2,3,7-tetrahydro-4H-pyrrolo[2,3-d]pyrimidin-4-one (1236764-86-5) + tert-butyl 4-bromobutyrate (110661-91-1) → Tert-butyl 4-({4-oxo-3-[4-(2,2,2-trifluoroethoxy)phenyl]-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-2-yl}sulfanyl)butanoate (1236766-41-8)

Guidance literature:

With sodium hydrogencarbonate; In water; N,N-dimethyl-formamide; at 100 ℃; for 1h;

Reference yield:

Tert-butyl 4-({4-oxo-3-[4-(2,2,2-trifluoroethoxy)phenyl]-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-2-yl}sulfanyl)butanoate (1236766-41-8) + methyl iodide (74-88-4) → tert-butyl 4-({7-methyl-4-oxo-3-[4-(2,2,2-trifluoroethoxy)phenyl]-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-2-yl}sulfanyl)butanoate (1236766-42-9)

Guidance literature:

With potassium tert-butylate; In N,N-dimethyl-formamide; at 20 ℃; for 18h;

Reference yield:

Tert-butyl 4-({4-oxo-3-[4-(2,2,2-trifluoroethoxy)phenyl]-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-2-yl}sulfanyl)butanoate (1236766-41-8) + ethyl iodide (75-03-6) → tert-butyl 4-({7-ethyl-4-oxo-3-[4-(2,2,2-trifluoroethoxy)phenyl]-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-2-yl}sulfanyl)butanoate (1236766-43-0)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 1h; Inert atmosphere;

upstream raw materials:

2-thioxo-3-[4-(2,2,2-trifluoroethoxy)phenyl]-1,2,3,7-tetrahydro-4H-pyrrolo[2,3-d]pyrimidin-4-one

tert-butyl 4-bromobutyrate

Downstream raw materials:

tert-butyl 4-({7-methyl-4-oxo-3-[4-(2,2,2-trifluoroethoxy)phenyl]-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-2-yl}sulfanyl)butanoate

tert-butyl 4-({7-ethyl-4-oxo-3-[4-(2,2,2-trifluoroethoxy)phenyl]-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-2-yl}sulfanyl)butanoate

tert-butyl 4-({7-(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)-4-oxo-3-[4-(2,2,2-trifluoroethoxy)phenyl]-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-2-yl}sulfanyl)butanoate

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