(1S,2R)-1-phenyl-2-[(S)-1-azido-3-tosyloxypropyl]-N,N-diethylcyclopropanecarboxamide

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Chemical Name:(1S,2R)-1-phenyl-2-[(S)-1-azido-3-tosyloxypropyl]-N,N-diethylcyclopropanecarboxamide
CAS No.:171889-29-5
Molecular Formula:C₂₄H₃₀N₄O₄S
Molecular Weight:470.593
Hs Code.:

Synonyms:(1S,2R)-1-phenyl-2-[(S)-1-azido-3-tosyloxypropyl]-N,N-diethylcyclopropanecarboxamide

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Chemical Property of (1S,2R)-1-phenyl-2-[(S)-1-azido-3-tosyloxypropyl]-N,N-diethylcyclopropanecarboxamide

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Technology Process of (1S,2R)-1-phenyl-2-[(S)-1-azido-3-tosyloxypropyl]-N,N-diethylcyclopropanecarboxamide

There total 5 articles about (1S,2R)-1-phenyl-2-[(S)-1-azido-3-tosyloxypropyl]-N,N-diethylcyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 98-59-9
p-toluenesulfonyl chloride

: 171889-28-4
(1S,2R)-1-phenyl-2-[(S)-1-azido-3-hydroxypropyl]-N,N-diethylcyclopropanecarboxamide

: 171889-29-5
(1S,2R)-1-phenyl-2-[(S)-1-azido-3-tosyloxypropyl]-N,N-diethylcyclopropanecarboxamide

Guidance literature:: With dmap; triethylamine; In dichloromethane; for 15h; Ambient temperature;
DOI:10.1021/jm960495w

Reference yield:

: 171889-27-3
2,2-Dimethyl-propionic acid (S)-3-azido-3-((1R,2S)-2-diethylcarbamoyl-2-phenyl-cyclopropyl)-propyl ester

: 171889-29-5
(1S,2R)-1-phenyl-2-[(S)-1-azido-3-tosyloxypropyl]-N,N-diethylcyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: 86 percent / NaOMe / methanol / 1 h / 20 °C

2: 99 percent / DMAP; Et₃N / CH₂Cl₂ / 9 h / 20 °C

With dmap; sodium methylate; triethylamine; In methanol; dichloromethane;
DOI:10.1039/b111540p

Reference yield:

: 171889-34-2
(1S,2R)-2-((S)-1,3-Dihydroxy-propyl)-1-phenyl-cyclopropanecarboxylic acid diethylamide

: 171889-29-5
(1S,2R)-1-phenyl-2-[(S)-1-azido-3-tosyloxypropyl]-N,N-diethylcyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: 88 percent / pyridine / 1.5 h / 0 °C

2: 91 percent / NaN₃, Ph₃P, CBr₄ / dimethylformamide / 3 h / Ambient temperature

3: 99 percent / MeONa, MeOH / 15 h / Ambient temperature

4: 99 percent / Et₃N, DMAP / CH₂Cl₂ / 15 h / Ambient temperature

With pyridine; methanol; dmap; sodium azide; carbon tetrabromide; sodium methylate; triethylamine; triphenylphosphine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm960495w