(4R,5R)-5-allyl-3,3-dichloro-4-[(S)-1-(2,4,6-triisopropylphenyl)ethoxy]pyrrolidin-2-one

Base Information

Chemical Name:(4R,5R)-5-allyl-3,3-dichloro-4-[(S)-1-(2,4,6-triisopropylphenyl)ethoxy]pyrrolidin-2-one
CAS No.:544711-64-0
Molecular Formula:C₂₄H₃₅Cl₂NO₂
Molecular Weight:440.453
Hs Code.:

Synonyms:(4R,5R)-5-allyl-3,3-dichloro-4-[(S)-1-(2,4,6-triisopropylphenyl)ethoxy]pyrrolidin-2-one

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Chemical Property of (4R,5R)-5-allyl-3,3-dichloro-4-[(S)-1-(2,4,6-triisopropylphenyl)ethoxy]pyrrolidin-2-one

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Technology Process of (4R,5R)-5-allyl-3,3-dichloro-4-[(S)-1-(2,4,6-triisopropylphenyl)ethoxy]pyrrolidin-2-one

There total 5 articles about (4R,5R)-5-allyl-3,3-dichloro-4-[(S)-1-(2,4,6-triisopropylphenyl)ethoxy]pyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 102225-88-7
(-)-(S)-1-(2,4,6-triisopropylphenyl)ethanol

: 544711-64-0
(4R,5R)-5-allyl-3,3-dichloro-4-[(S)-1-(2,4,6-triisopropylphenyl)ethoxy]pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium hydride / tetrahydrofuran / 2 h

1.2: 79 percent / tetrahydrofuran / 2.5 h / -50 - 20 °C

2.1: n-butyllithium / hexane; tetrahydrofuran / -90 - -40 °C

2.2: HMPA / tetrahydrofuran; hexane / -40 - 0 °C

3.1: H₂; ethylenediamine; 1-hexene / Pd/BaSO₄ / dimethylformamide / 9 h / 0 °C

3.2: Zn-Cu couple / diethyl ether / 1 h / 20 °C

3.3: O-mesitylenesulfonylhydroxylamine; Na₂SO₄ / CH₂Cl₂ / 9 h / 20 °C

With n-butyllithium; 1-hexene; hydrogen; potassium hydride; ethylenediamine; Pd-BaSO₄; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;
DOI:10.1021/jo050983o

Reference yield:

: 220416-57-9
2-((1S)-1-((1E)-1,2-dichloroethenyloxy)ethyl)-1,3,5-triisopropylbenzene

: 544711-64-0
(4R,5R)-5-allyl-3,3-dichloro-4-[(S)-1-(2,4,6-triisopropylphenyl)ethoxy]pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / hexane; tetrahydrofuran / -90 - -40 °C

1.2: HMPA / tetrahydrofuran; hexane / -40 - 0 °C

2.1: H₂; ethylenediamine; 1-hexene / Pd/BaSO₄ / dimethylformamide / 9 h / 0 °C

2.2: Zn-Cu couple / diethyl ether / 1 h / 20 °C

2.3: O-mesitylenesulfonylhydroxylamine; Na₂SO₄ / CH₂Cl₂ / 9 h / 20 °C

With n-butyllithium; 1-hexene; hydrogen; ethylenediamine; Pd-BaSO₄; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;
DOI:10.1021/jo050983o

Reference yield:

: 76-02-8
trifluoroacetyl chloride

: 544711-62-8
2-[(S)-1-(pent-4-en-1-ynyloxy)ethyl]-1,3,5-triisopropylbenzene

: 5-allyl-3,3-dichloro-4-[(S)-1-(2,4,6-triisopropylphenyl)ethoxy]pyrrolidin-2-one

: 544711-64-0
(4R,5R)-5-allyl-3,3-dichloro-4-[(S)-1-(2,4,6-triisopropylphenyl)ethoxy]pyrrolidin-2-one

Guidance literature:: 2-[(S)-1-(pent-4-en-1-ynyloxy)ethyl]-1,3,5-triisopropylbenzene; With 1-hexene; hydrogen; ethylenediamine; Pd-BaSO₄; In N,N-dimethyl-formamide; at 0 ℃; for 9h;

trifluoroacetyl chloride; With copper; zinc; In diethyl ether; at 20 ℃; for 1h;

With mesitylenesulfonylhydroxylamine; sodium sulfate; In dichloromethane; at 20 ℃; for 9h; Title compound not separated from byproducts;
DOI:10.1021/jo050983o