2-{(4S,6S)-6-[2-(benzyloxy)ethyl]-2,2-dimethyl-1,3-dioxan-4-yl}acetamide

Base Information

• Chemical Name: 2-{(4S,6S)-6-[2-(benzyloxy)ethyl]-2,2-dimethyl-1,3-dioxan-4-yl}acetamide
• CAS No.: 1431291-03-0
• Molecular Formula: C₁₇H₂₅NO₄
• Molecular Weight: 307.39

Synonyms:2-{(4S,6S)-6-[2-(benzyloxy)ethyl]-2,2-dimethyl-1,3-dioxan-4-yl}acetamide

Chemical Property of 2-{(4S,6S)-6-[2-(benzyloxy)ethyl]-2,2-dimethyl-1,3-dioxan-4-yl}acetamide

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of 2-{(4S,6S)-6-[2-(benzyloxy)ethyl]-2,2-dimethyl-1,3-dioxan-4-yl}acetamide

There total 2 articles about 2-{(4S,6S)-6-[2-(benzyloxy)ethyl]-2,2-dimethyl-1,3-dioxan-4-yl}acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

methyl 2-{(4S,6S)-6-[2-(benzyloxy)ethyl]-2,2-dimethyl-1,3-dioxan-4-yl}acetate (1431291-02-9) → 2-{(4S,6S)-6-[2-(benzyloxy)ethyl]-2,2-dimethyl-1,3-dioxan-4-yl}acetamide (1431291-03-0)

Guidance literature:

With ammonium hydroxide; In methanol; water; for 48h; Inert atmosphere;

DOI:10.1002/ejoc.201201154

Reference yield:

2,2-dimethoxy-propane (77-76-9) → 2-{(4S,6S)-6-[2-(benzyloxy)ethyl]-2,2-dimethyl-1,3-dioxan-4-yl}acetamide (1431291-03-0)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid / dichloromethane / 24 h / Reflux; Inert atmosphere

2: ammonium hydroxide / methanol; water / 48 h / Inert atmosphere

With ammonium hydroxide; toluene-4-sulfonic acid; In methanol; dichloromethane; water;

DOI:10.1002/ejoc.201201154

Reference yield: 72.0%

2-{(4S,6S)-6-[2-(benzyloxy)ethyl]-2,2-dimethyl-1,3-dioxan-4-yl}acetamide (1431291-03-0) → 2-{(4R,6S)-6-[2-(benzyloxy)ethyl]-2,2-dimethyl-1,3-dioxan-4-yl}ethylamine (1262052-10-7)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 12h; Inert atmosphere; Reflux;

DOI:10.1002/ejoc.201201154

upstream raw materials:

2,2-dimethoxy-propane

methyl 2-{(4S,6S)-6-[2-(benzyloxy)ethyl]-2,2-dimethyl-1,3-dioxan-4-yl}acetate

Downstream raw materials:

1-(2-{(4R,6S)-6-[2-(benzyloxy)ethyl]-2,2-dimethyl-1,3-dioxan-4-yl}ethyl)-N-[4-(2,2-dimethyl-3,3-diphenyl-4,7,10,13-tetraoxa-3-silahexadec-16-yl)phenyl]-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxamide

N-[4-(2,2-dimethyl-3,3-diphenyl-4,7,10,13-tetraoxa-3-silahexadec-16-yl)phenyl]-5-(4-fluorophenyl)-1-{2-[(4R,6S)-6-(2-hydroxyethyl)-2,2-dimethyl-1,3-dioxan-4-yl]ethyl}-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxamide

2-{(4R,6R)-6-[2-(3-{[4-(2,2-dimethyl-3,3-diphenyl-4,7,10,13-tetraoxa-3-silahexadec-16-yl)phenyl]carbamoyl}-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrol-1-yl)ethyl]-2,2-dimethyl-1,3-dioxan-4-yl}acetic acid

N-[4-(2,2-dimethyl-3,3-diphenyl-4,7,10,13-tetraoxa-3-silahexadec-16-yl)phenyl]-5-(4-fluorophenyl)-1-{2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxamide

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