tert-butyl N-{6-[5-chloro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrazin-2-yl}-L-alaninate

Base Information

Chemical Name:tert-butyl N-{6-[5-chloro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrazin-2-yl}-L-alaninate
CAS No.:1346172-28-8
Molecular Formula:C₂₄H₂₄ClN₅O₄S
Molecular Weight:514.005
Hs Code.:

Synonyms:tert-butyl N-{6-[5-chloro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrazin-2-yl}-L-alaninate

Suppliers and Price of tert-butyl N-{6-[5-chloro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrazin-2-yl}-L-alaninate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of tert-butyl N-{6-[5-chloro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrazin-2-yl}-L-alaninate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of tert-butyl N-{6-[5-chloro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrazin-2-yl}-L-alaninate

There total 9 articles about tert-butyl N-{6-[5-chloro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrazin-2-yl}-L-alaninate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1346172-27-7
tert-butyl N-(6-chloropyrazin-2-yl)-L-alaninate

: 1363407-75-3
potassium (5-chloro-1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)trifluoroborate

: 1346172-28-8
tert-butyl N-{6-[5-chloro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrazin-2-yl}-L-alaninate

Guidance literature:: With triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In propan-1-ol; at 100 ℃; for 1h;

Reference yield:

: 21691-50-9
Ala-OtBu

: 1346172-28-8
tert-butyl N-{6-[5-chloro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrazin-2-yl}-L-alaninate

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 16 h / 80 °C / Inert atmosphere

2: triethylamine / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / propan-1-ol / 1 h / 100 °C

With triethylamine; N-ethyl-N,N-diisopropylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In propan-1-ol; isopropyl alcohol;

Reference yield:

: 1072-98-6
5-chloro-2-pyridylamine

: 1346172-28-8
tert-butyl N-{6-[5-chloro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrazin-2-yl}-L-alaninate

Guidance literature:: Multi-step reaction with 8 steps

1.1: iodine; sulfuric acid; periodic acid / ethanol; water / 15 h / 80 °C

1.2: pH 9

2.1: triethylamine; copper(l) iodide / bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 1.67 h / 20 - 40 °C / Inert atmosphere

3.1: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 4 h / 80 °C / Inert atmosphere

4.1: bromine; acetic acid / 3 h / 90 °C

5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.83 h / 0 °C / Inert atmosphere

5.2: 1.5 h / 0 - 25 °C

6.1: potassium acetate / palladium bis[bis(diphenylphosphino)ferrocene] dichloride / 1,2-dimethoxyethane / 6 h / 86 °C / Inert atmosphere

7.1: water; acetone / 20 °C

8.1: triethylamine / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / propan-1-ol / 1 h / 100 °C

With copper(l) iodide; sulfuric acid; potassium tert-butylate; bromine; iodine; potassium acetate; sodium hydride; acetic acid; periodic acid; triethylamine; bis-triphenylphosphine-palladium(II) chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; propan-1-ol; 1,2-dimethoxyethane; ethanol; water; N,N-dimethyl-formamide; acetone; mineral oil;