Benzoic acid, 3-(ethylamino)-4-hydroxy-, methyl ester (9CI)

Base Information

• Chemical Name: Benzoic acid, 3-(ethylamino)-4-hydroxy-, methyl ester (9CI)
• CAS No.: 220844-96-2
• Molecular Formula: C₁₀H₁₃NO₃
• Molecular Weight: 195.218
• Mol file: 220844-96-2.mol

Synonyms:Benzoic acid, 3-(ethylamino)-4-hydroxy-, methyl ester (9CI)

Chemical Property of Benzoic acid, 3-(ethylamino)-4-hydroxy-, methyl ester (9CI)

Chemical Property:

• PSA: 58.56000
• LogP: 1.68360

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzoic acid, 3-(ethylamino)-4-hydroxy-, methyl ester (9CI)

There total 3 articles about Benzoic acid, 3-(ethylamino)-4-hydroxy-, methyl ester (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

ethyl iodide (75-03-6) + methyl 3-amino-4-hydroxybenzoate (536-25-4) → methyl 4-hydroxy-3-ethylaminobenzoate (220844-96-2)

Guidance literature:

With sodium hydrogencarbonate; In acetonitrile; for 5h; Heating;

DOI:10.1248/cpb.47.22

Reference yield:

methyl (4S,5R)-4,5-dihydroxy-3-oxo-1-cyclohexene-1-carboxylate (84806-48-4) + ethylamine (75-04-7,85404-22-4) → methyl 4-hydroxy-3-ethylaminobenzoate (220844-96-2)

Guidance literature:

With toluene-4-sulfonic acid; 1,2-dichloro-ethane; In dimethyl sulfoxide; at 110 ℃; for 8h; Microwave irradiation;

DOI:10.1039/c3ra47221c

Reference yield:

methanol (67-56-1) → methyl 4-hydroxy-3-ethylaminobenzoate (220844-96-2)

Guidance literature:

With hydrogenchloride;

upstream raw materials:

ethyl iodide

methyl 3-amino-4-hydroxybenzoate

methanol

methyl (4S,5R)-4,5-dihydroxy-3-oxo-1-cyclohexene-1-carboxylate

Downstream raw materials:

4-(2-bromo-2-methyl-propionyloxy)-3-ethylamino-benzoic acid methyl ester

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