N,N-bis(trifluoromethyl)hydroxylamine

Base Information

• Chemical Name: N,N-bis(trifluoromethyl)hydroxylamine
• CAS No.: 359-63-7
• Molecular Formula: C2H F6 N O
• Molecular Weight: 169.026
• Hs Code.: 2928000090
• DSSTox Substance ID: DTXSID20371168
• Nikkaji Number: J589.535I
• Wikidata: Q81985746
• Mol file: 359-63-7.mol

Synonyms:N,N-bis(trifluoromethyl)hydroxylamine;359-63-7;SCHEMBL815119;DTXSID20371168;OGYLARHBIDXOMV-UHFFFAOYSA-N;AKOS006229905;FT-0748908

Chemical Property of N,N-bis(trifluoromethyl)hydroxylamine

Chemical Property:

• Boiling Point: 33°C
• PSA: 23.47000
• LogP: 1.71720
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 0
• Exact Mass: 168.99623263
• Heavy Atom Count: 10
• Complexity: 99.9

Purity/Quality:

98%min ^*data from raw suppliers

N,N-BIS(TRIFLUOROMETHYL)HYDROXYLAMINE 98.00% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: T
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(N(C(F)(F)F)O)(F)(F)F

Technology Process of N,N-bis(trifluoromethyl)hydroxylamine

There total 21 articles about N,N-bis(trifluoromethyl)hydroxylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

benzyl azide (622-79-7) → N,N-bis(trifluoromethyl)hydroxylamine (359-63-7) + benzonitrile (100-47-0)

Guidance literature:

With bis-trifluoromethyl-aminooxyl; In tetrachloromethane; at 20 ℃; for 0.5h; Mechanism; analogous reactions of other benzyl derivatives (PhCH₂CN, PhCH₂Cl, and PhCH₂OH);

DOI:10.1039/P19810000455

Reference yield: 93.0%

bis-trifluoromethyl-aminooxyl (2154-71-4) + methoxybenzene (100-66-3) → N,N-Bis(trifluoromethyl)amine (371-77-7) + N,N-bis(trifluoromethyl)hydroxylamine (359-63-7) + Perfluoro-2-azapropen (371-71-1) + O-Phenoxymethyl-N,N-bis-trifluoromethyl-hydroxylamine (78073-50-4)

Guidance literature:

at 20 ℃; for 24h;

DOI:10.1039/P19810001068

Reference yield: 85.0%

Dichloromethylsilane (75-54-7) + bis-trifluoromethyl-aminooxyl (2154-71-4) → trifluoronitrosomethane (334-99-6) + N,N-bis(trifluoromethyl)hydroxylamine (359-63-7) + dichloromethylsilane (58310-34-2)

Guidance literature:

for 6h; Ambient temperature; in vacuo;

DOI:10.1016/0022-1139(93)02976-L

upstream raw materials:

bis(trifluoromethyl)ketimine

bis-trifluoromethyl-aminooxyl

hexafluoroacetone oxime

α-(bistrifluoromethylamino-oxy)benzyl cyanide

Downstream raw materials:

bis(trifluoromethylamino-oxy)cyclo-octane

1-(bistrifluoromethylamino-oxy)-1-methylcycloheptane

1-(bistrifluoromethylamino-oxy)-1,2-dimethylcyclohexane

Vinyl bromide

Refernces

• 1、 Fisher, R.,Haszeldine, R. N.,Tipping, A. E.. "PERFLUOROALKYL DERIVATIVES OF NITROGEN. PART LIII. REACTION OF PERFLUORO(2,5-DIMETHYL-4-OXA-3,5-DIAZAHEX-2-ENE) WITH FLUORO-OLEFINS". . p. 155 - 164. Retrieved 1983.
• 2、 Connelly, Gregory D.,Tipping, Anthony E.. "The reaction of bis(trifluoromethyl)amino-oxyl with t-butyl bromide, t-butyl chloride, 2,2-dichloropropane, 2-chloro-2-phenylpropane and t-butyl acetate". . p. 83 - 92. Retrieved 2007/10/02.
• 3、 Bell, David,Tipping, Anthony E.. "Unsaturated nitrogen compounds containing fluorine. Part 13. Reaction of 2--1,1,1,3,3,3-hexafluoropropan-2-ide with compounds containing N=O or N-O bonds". . p. 279 - 286. Retrieved 2007/10/02.