(R)-2-Methylamino-3-phenyl-N-((S)-2-phenyl-1-thiazol-2-yl-ethyl)-propionamide

Base Information

Chemical Name:(R)-2-Methylamino-3-phenyl-N-((S)-2-phenyl-1-thiazol-2-yl-ethyl)-propionamide
CAS No.:713124-84-6
Molecular Formula:C₂₁H₂₃N₃OS
Molecular Weight:365.499
Hs Code.:

Synonyms:(R)-2-Methylamino-3-phenyl-N-((S)-2-phenyl-1-thiazol-2-yl-ethyl)-propionamide

Suppliers and Price of (R)-2-Methylamino-3-phenyl-N-((S)-2-phenyl-1-thiazol-2-yl-ethyl)-propionamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-2-Methylamino-3-phenyl-N-((S)-2-phenyl-1-thiazol-2-yl-ethyl)-propionamide

Chemical Property:

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Technology Process of (R)-2-Methylamino-3-phenyl-N-((S)-2-phenyl-1-thiazol-2-yl-ethyl)-propionamide

There total 4 articles about (R)-2-Methylamino-3-phenyl-N-((S)-2-phenyl-1-thiazol-2-yl-ethyl)-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2448-45-5
Cbz-D-Phe

: 713124-84-6
(R)-2-Methylamino-3-phenyl-N-((S)-2-phenyl-1-thiazol-2-yl-ethyl)-propionamide

Guidance literature:: Multi-step reaction with 3 steps

1: 97.5 percent / sodium hydride / tetrahydrofuran / 22 h / 0 - 20 °C

2: 98 percent / triethylamine; diethyl phosphorocyanidate / CH₂Cl₂ / 0.33 h / 0 °C

3: HBr; acetic acid / 1 h / 20 °C

With diethyl cyanophosphonate; hydrogen bromide; sodium hydride; acetic acid; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo030358o

Reference yield:

: 713124-83-5
Methyl-[(R)-2-phenyl-1-((S)-2-phenyl-1-thiazol-2-yl-ethylcarbamoyl)-ethyl]-carbamic acid benzyl ester

: 713124-84-6
(R)-2-Methylamino-3-phenyl-N-((S)-2-phenyl-1-thiazol-2-yl-ethyl)-propionamide

Guidance literature:: With hydrogen bromide; acetic acid; at 20 ℃; for 1h;
DOI:10.1021/jo030358o

Reference yield:

: 130199-65-4
(1S)-2-phenyl-1-(1,3-thiazol-2-yl)ethan-1-amine

: 713124-84-6
(R)-2-Methylamino-3-phenyl-N-((S)-2-phenyl-1-thiazol-2-yl-ethyl)-propionamide

Guidance literature:: Multi-step reaction with 2 steps

1: 98 percent / triethylamine; diethyl phosphorocyanidate / CH₂Cl₂ / 0.33 h / 0 °C

2: HBr; acetic acid / 1 h / 20 °C

With diethyl cyanophosphonate; hydrogen bromide; acetic acid; triethylamine; In dichloromethane;
DOI:10.1021/jo030358o