Methyl-[(R)-2-phenyl-1-((S)-2-phenyl-1-thiazol-2-yl-ethylcarbamoyl)-ethyl]-carbamic acid benzyl ester

Base Information

• Chemical Name: Methyl-[(R)-2-phenyl-1-((S)-2-phenyl-1-thiazol-2-yl-ethylcarbamoyl)-ethyl]-carbamic acid benzyl ester
• CAS No.: 713124-83-5
• Molecular Formula: C₂₉H₂₉N₃O₃S
• Molecular Weight: 499.634
• Mol file: 713124-83-5.mol

Synonyms:Methyl-[(R)-2-phenyl-1-((S)-2-phenyl-1-thiazol-2-yl-ethylcarbamoyl)-ethyl]-carbamic acid benzyl ester

Chemical Property of Methyl-[(R)-2-phenyl-1-((S)-2-phenyl-1-thiazol-2-yl-ethylcarbamoyl)-ethyl]-carbamic acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Methyl-[(R)-2-phenyl-1-((S)-2-phenyl-1-thiazol-2-yl-ethylcarbamoyl)-ethyl]-carbamic acid benzyl ester

There total 2 articles about Methyl-[(R)-2-phenyl-1-((S)-2-phenyl-1-thiazol-2-yl-ethylcarbamoyl)-ethyl]-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(1S)-2-phenyl-1-(1,3-thiazol-2-yl)ethan-1-amine (130199-65-4) + (2R)-2-[[(benzyloxy)carbonyl](methyl)amino]-3-phenylpropanoic acid (114526-00-0) → Methyl-[(R)-2-phenyl-1-((S)-2-phenyl-1-thiazol-2-yl-ethylcarbamoyl)-ethyl]-carbamic acid benzyl ester (713124-83-5)

Guidance literature:

With diethyl cyanophosphonate; triethylamine; In dichloromethane; at 0 ℃; for 0.333333h;

DOI:10.1021/jo030358o

Reference yield:

Cbz-D-Phe (2448-45-5) → Methyl-[(R)-2-phenyl-1-((S)-2-phenyl-1-thiazol-2-yl-ethylcarbamoyl)-ethyl]-carbamic acid benzyl ester (713124-83-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 97.5 percent / sodium hydride / tetrahydrofuran / 22 h / 0 - 20 °C

2: 98 percent / triethylamine; diethyl phosphorocyanidate / CH₂Cl₂ / 0.33 h / 0 °C

With diethyl cyanophosphonate; sodium hydride; triethylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jo030358o

Reference yield:

Methyl-[(R)-2-phenyl-1-((S)-2-phenyl-1-thiazol-2-yl-ethylcarbamoyl)-ethyl]-carbamic acid benzyl ester (713124-83-5) → (R)-2-Methylamino-3-phenyl-N-((S)-2-phenyl-1-thiazol-2-yl-ethyl)-propionamide (713124-84-6)

Guidance literature:

With hydrogen bromide; acetic acid; at 20 ℃; for 1h;

DOI:10.1021/jo030358o

upstream raw materials:

(1S)-2-phenyl-1-(1,3-thiazol-2-yl)ethan-1-amine

(2R)-2-[[(benzyloxy)carbonyl](methyl)amino]-3-phenylpropanoic acid

Cbz-D-Phe

Downstream raw materials:

(R)-2-Methylamino-3-phenyl-N-((S)-2-phenyl-1-thiazol-2-yl-ethyl)-propionamide

(S)-2-Amino-4-methyl-pentanoic acid methyl-[(R)-2-phenyl-1-((S)-2-phenyl-1-thiazol-2-yl-ethylcarbamoyl)-ethyl]-amide

((S)-3-Methyl-1-{methyl-[(R)-2-phenyl-1-((S)-2-phenyl-1-thiazol-2-yl-ethylcarbamoyl)-ethyl]-carbamoyl}-butyl)-carbamic acid 9H-fluoren-9-ylmethyl ester