2,3-dihydro-2-benzofuryl phenyl ketone

Base Information

• Chemical Name: 2,3-dihydro-2-benzofuryl phenyl ketone
• CAS No.: 80467-73-8
• Molecular Formula: C₁₅H₁₁BrO₂
• Molecular Weight: 303.155
• Mol file: 80467-73-8.mol

Synonyms:2,3-dihydro-2-benzofuryl phenyl ketone

Chemical Property of 2,3-dihydro-2-benzofuryl phenyl ketone

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,3-dihydro-2-benzofuryl phenyl ketone

There total 3 articles about 2,3-dihydro-2-benzofuryl phenyl ketone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

C13H20Br2OSi + (benzoylmethylene)dimethylsulfurane (5633-34-1) → 2,3-dihydro-2-benzofuryl phenyl ketone (80467-73-8)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; dichloromethane; at 20 ℃; for 4h; Inert atmosphere;

DOI:10.1039/c4ra17003b

Reference yield: 40.0%

6-bromo-3-cinnamoyl-2H-chromen-2-one (80467-51-2) + acetophenone (98-86-2) + methylamine (74-89-5) → 2,3-dihydro-2-benzofuryl phenyl ketone (80467-73-8) + 4-Benzoyl-3-methylamino-5-phenyl-cyclohex-3-enone (80467-69-2)

Guidance literature:

In ethanol; 1) room temperature, 5-7 d, 2) steam-bath, 1 h;

Reference yield:

3-Acetyl-6-bromo-chromen-2-one (2199-93-1) → 2,3-dihydro-2-benzofuryl phenyl ketone (80467-73-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 50 percent / piperidine / butan-1-ol / 4 h / Heating

2: 20 percent / ethanol / 1) room temperature, 5-7 d, 2) steam-bath, 1 h

piperidine; In ethanol; butan-1-ol;

upstream raw materials:

6-bromo-3-cinnamoyl-2H-chromen-2-one

acetophenone

methylamine

3-Acetyl-6-bromo-chromen-2-one