diphenyl <1-<(benzyloxycarbonyl)amino>-3-(phenylthio)propyl>phosphonate

Base Information

• Chemical Name: diphenyl <1-<(benzyloxycarbonyl)amino>-3-(phenylthio)propyl>phosphonate
• CAS No.: 100432-03-9
• Molecular Formula: C₂₉H₂₈NO₅PS
• Molecular Weight: 533.585
• Mol file: 100432-03-9.mol

Synonyms:diphenyl <1-<(benzyloxycarbonyl)amino>-3-(phenylthio)propyl>phosphonate

Chemical Property of diphenyl <1-<(benzyloxycarbonyl)amino>-3-(phenylthio)propyl>phosphonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of diphenyl <1-<(benzyloxycarbonyl)amino>-3-(phenylthio)propyl>phosphonate

There total 3 articles about diphenyl <1-<(benzyloxycarbonyl)amino>-3-(phenylthio)propyl>phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

triphenyl phosphite (101-02-0) + O-benzyl carbamate (621-84-1) + 3-phenylsulfanyl-propionaldehyde (27098-65-3) → diphenyl <1-<(benzyloxycarbonyl)amino>-3-(phenylthio)propyl>phosphonate (100432-03-9)

Guidance literature:

With acetic acid; at 80 ℃; for 1h;

Reference yield: 43.0%

O-benzyl carbamate (621-84-1) + phosphoric acid triphenyl ester (115-86-6) + 3-phenylsulfanyl-propionaldehyde (27098-65-3) → diphenyl <1-<(benzyloxycarbonyl)amino>-3-(phenylthio)propyl>phosphonate (100432-03-9)

Guidance literature:

With acetic acid; at 80 - 85 ℃; for 1h;

DOI:10.1021/jm00154a024

Reference yield:

thiophenol (108-98-5) → diphenyl <1-<(benzyloxycarbonyl)amino>-3-(phenylthio)propyl>phosphonate (100432-03-9)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 0 - 20 °C

2: acetic acid / 1 h / 80 °C

With acetic acid; triethylamine; In dichloromethane;

upstream raw materials:

O-benzyl carbamate

phosphoric acid triphenyl ester

3-phenylsulfanyl-propionaldehyde

triphenyl phosphite

Downstream raw materials:

diphenyl <1-<(benzyloxycarbonyl)amino>-3-(phenylsulfinyl)propyl>phosphonate

diphenyl <1-<(benzyloxycarbonyl)amino>-2-propenyl>phosphonate

dimethyl [(RS)-1-(benzyloxycarbonylamino)-3-(phenylsulfanyl)propyl]phosphonate

[3-(phenylsulfanyl)-1-(RS)-(diphenoxyphosphoryl)propan-1-aminium] bromide