4-carboxy-3-chloroacetophenone

Base Information

• Chemical Name: 4-carboxy-3-chloroacetophenone
• CAS No.: 115382-35-9
• Molecular Formula: C₉H₇ClO₃
• Molecular Weight: 198.606
• Hs Code.: 2916399090
• Mol file: 115382-35-9.mol

Synonyms:4-carboxy-3-chloroacetophenone

Chemical Property of 4-carboxy-3-chloroacetophenone

Chemical Property:

• Melting Point: 228 °C
• Boiling Point: 375.6±32.0 °C(Predicted)
• PKA: 2.34±0.25(Predicted)
• Density: 1.365±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98% ^*data from raw suppliers

4-Acetyl-2-chlorobenzoic acid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-carboxy-3-chloroacetophenone

There total 3 articles about 4-carboxy-3-chloroacetophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

carbon dioxide (124-38-9,18923-20-1) + 3',4'-dichloroacetophenone (2642-63-9) → 5-acetyl-2-chloro-benzoic acid (98588-66-0) + 4-carboxy-3-chloroacetophenone (115382-35-9) + methoxybenzene (100-66-3) + 3'-Chloroacetophenone (99-02-5)

Guidance literature:

With tetrabutylammomium bromide; In N,N-dimethyl-formamide; at 5 ℃; Yields of byproduct given; electrolysis (I=0.4 A);

DOI:10.1016/S0040-4020(01)86724-7

Reference yield:

→ 4-carboxy-3-chloroacetophenone (115382-35-9)

Guidance literature:

With alkaline aqueous potassium permanganate solution;

DOI:10.1039/jr9340000852

Reference yield:

tetrachloromethane (56-23-5) + 1-(3-chloro-4-methylphenyl)-ethanone (90792-98-6) + water (7732-18-5) → 4-carboxy-3-chloroacetophenone (115382-35-9)

Guidance literature:

DOI:10.1039/jr9340000848

upstream raw materials:

carbon dioxide

3',4'-dichloroacetophenone

tetrachloromethane

1-(3-chloro-4-methylphenyl)-ethanone

Refernces