DIETHYL BENZYLSUCCINATE

Base Information

• Chemical Name: DIETHYL BENZYLSUCCINATE
• CAS No.: 21307-94-8
• Molecular Formula: C₁₅H₂₀O₄
• Molecular Weight: 264.321
• Mol file: 21307-94-8.mol

Synonyms:DIETHYL BENZYLSUCCINATE;Diethyl bbenzylsuccinate

Chemical Property of DIETHYL BENZYLSUCCINATE

Chemical Property:

• PSA: 52.60000
• LogP: 2.36160

Purity/Quality:

95% ^*data from raw suppliers

DIETHYL BENZYLSUCCINATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of DIETHYL BENZYLSUCCINATE

There total 32 articles about DIETHYL BENZYLSUCCINATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

2-benzylsuccinic acid (36092-42-9,884-33-3) + 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride (25952-53-8) → 1,4-diethyl 2-benzylsuccinate (21654-18-2,79909-18-5,21307-94-8)

Guidance literature:

With dmap; In ethanol; dichloromethane; for 0.5h;

DOI:10.1021/ja2092689

Reference yield: 68.0%

but-2-enedioic acid diethyl ester (1520-50-9) + benzyl alcohol (100-51-6,185532-71-2) → 1,4-diethyl 2-benzylsuccinate (21654-18-2,79909-18-5,21307-94-8)

Guidance literature:

With piperidine; iododioxobis(triphenylphosphine)rhenium(V); In benzene; at 150 ℃; for 24h; Inert atmosphere; Sealed tube;

DOI:10.1021/acs.joc.9b03150

Reference yield: 38.0%

ethanol (64-17-5) + (R)-3-benzyl-4-methoxy-4-oxobutanoic acid (119807-84-0) → diethyl (2R)-2-benzylsuccinate (21307-94-8)

Guidance literature:

(R)-3-benzyl-4-methoxy-4-oxobutanoic acid; With potassium carbonate; In tetrahydrofuran; water; at 20 ℃;

ethanol; With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1021/ja2092689

upstream raw materials:

ethanol

2-benzylsuccinic acid

diethyl (Z)-2-benzylidenesuccinate

succinic acid diethyl ester