3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-phenylpropanoic acid

Base Information

Chemical Name:3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-phenylpropanoic acid
CAS No.:83256-46-6
Molecular Formula:C₁₇H₁₃NO₄
Molecular Weight:295.295
Hs Code.:
DSSTox Substance ID:DTXSID801331242
Nikkaji Number:J3.548.337C
ChEMBL ID:CHEMBL1731083

Synonyms:3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-phenylpropanoic acid;83256-46-6;ChemDiv3_000219;Cambridge id 5109324;Oprea1_221527;Oprea1_792205;CBDivE_010573;MLS001077215;3-(1,3-dioxoisoindol-2-yl)-3-phenylpropanoic acid;SCHEMBL6689045;CHEMBL1731083;DTXSID801331242;HMS1473J21;HMS2789L23;CCG-15242;STK071735;3-Phthalimidyl-3-phenylpropionic acid;AKOS000143748;AKOS016050834;IDI1_019537;NCGC00177205-01;SMR000472998;J3.548.337C;AB00073888-01;SR-01000391874;SR-01000391874-1;Z56755945

Suppliers and Price of 3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-phenylpropanoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-phenylpropanoic acid

Chemical Property:

XLogP3:1.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:295.08445790
Heavy Atom Count:22
Complexity:445

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC=C(C=C1)C(CC(=O)O)N2C(=O)C3=CC=CC=C3C2=O

Technology Process of 3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-phenylpropanoic acid

There total 12 articles about 3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-phenylpropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 64-18-6
formic acid

: 3480-56-6
2-(1-phenyl-vinyl)-isoindole-1,3-dione

: 83256-46-6
3-(1,3-dioxoisoindolin-2-yl)-3-phenylpropanoic acid

Guidance literature:: With bis(η3-allyl-μ-chloropalladium(II)); phenyl formate; bis[2-(diphenylphosphino)phenyl] ether; In toluene; at 80 ℃; for 24h; regioselective reaction; Inert atmosphere;
DOI:10.1039/c5ob01304f

Reference yield:

: 100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6
styrene

: 136918-14-4,85-41-6
phthalimide

: 201230-82-2
carbon monoxide

: 83256-46-6
3-(1,3-dioxoisoindolin-2-yl)-3-phenylpropanoic acid

Guidance literature:: With palladium(II) trifluoroacetate; [bis(acetoxy)iodo]benzene; trifluoroacetic acid; In toluene; acetonitrile; at 60 ℃; for 26h; under 760.051 Torr; Concentration; Reagent/catalyst; Schlenk technique;
DOI:10.1021/jacs.5b00719

Reference yield:

: 100-52-7
benzaldehyde

: 83256-46-6
3-(1,3-dioxoisoindolin-2-yl)-3-phenylpropanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: ammonium acetate / ethanol / Heating

2: sodium carbonate / acetonitrile; H₂O

With ammonium acetate; sodium carbonate; In ethanol; water; acetonitrile;
DOI:10.1021/jm9603328