2-{[(E)-7-Benzo[1,3]dioxol-5-yl-1-(toluene-4-sulfonylmethyl)-hept-1-enyl]-formyl-amino}-benzoic acid methyl ester

Base Information

Chemical Name:2-{[(E)-7-Benzo[1,3]dioxol-5-yl-1-(toluene-4-sulfonylmethyl)-hept-1-enyl]-formyl-amino}-benzoic acid methyl ester
CAS No.:474452-40-9
Molecular Formula:C₃₁H₃₃NO₇S
Molecular Weight:563.672
Hs Code.:

Synonyms:2-{[(E)-7-Benzo[1,3]dioxol-5-yl-1-(toluene-4-sulfonylmethyl)-hept-1-enyl]-formyl-amino}-benzoic acid methyl ester

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Chemical Property of 2-{[(E)-7-Benzo[1,3]dioxol-5-yl-1-(toluene-4-sulfonylmethyl)-hept-1-enyl]-formyl-amino}-benzoic acid methyl ester

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Technology Process of 2-{[(E)-7-Benzo[1,3]dioxol-5-yl-1-(toluene-4-sulfonylmethyl)-hept-1-enyl]-formyl-amino}-benzoic acid methyl ester

There total 11 articles about 2-{[(E)-7-Benzo[1,3]dioxol-5-yl-1-(toluene-4-sulfonylmethyl)-hept-1-enyl]-formyl-amino}-benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 67-56-1
methanol

: 201230-82-2
carbon monoxide

: 474452-42-1
N-[7-benzo[1,3]dioxol-5-yl-1-(toluene-4-sulfonylmethyl)-hept-1-enyl]-N-(2-iodo-phenyl)-formamide

: 474452-40-9
2-{[(E)-7-Benzo[1,3]dioxol-5-yl-1-(toluene-4-sulfonylmethyl)-hept-1-enyl]-formyl-amino}-benzoic acid methyl ester

Guidance literature:: With triethylamine; palladium diacetate; at 70 ℃; for 48h; under 20520 Torr;
DOI:10.1021/jo026595t

Reference yield: 26.0%

: 41270-80-8
N-formylanthranilic acid methyl ester

: 474452-37-4
4-[8-(p-toluenesulfonyl)-7-octynyl]-1,2-(methylenedioxy)benzene

: 474452-40-9
2-{[(E)-7-Benzo[1,3]dioxol-5-yl-1-(toluene-4-sulfonylmethyl)-hept-1-enyl]-formyl-amino}-benzoic acid methyl ester

Guidance literature:: With dmap; potassium carbonate; In water; N,N-dimethyl-formamide; at 20 ℃; for 15h;
DOI:10.1021/jo026595t

Reference yield:

: 2635-13-4
1,2-(methylenedioxy)-4-bromobenzene

: 474452-40-9
2-{[(E)-7-Benzo[1,3]dioxol-5-yl-1-(toluene-4-sulfonylmethyl)-hept-1-enyl]-formyl-amino}-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 9 steps

1.1: tert-butyllithium / tetrahydrofuran; pentane / 0.42 h / -78 - -42 °C

1.2: tetrahydrofuran; pentane / -78 - 20 °C

2.1: NaI / acetone / 48 h / Heating

3.1: n-butyllithium / tetrahydrofuran; hexane / 0 - 20 °C

3.2: HMPA / tetrahydrofuran; hexane / 48 h / 20 °C

4.1: 1.38 g / tetrabutylammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C

5.1: CHCl₃ / 2 h / Irradiation

6.1: m-chloroperbenzoic acid / CHCl₃ / 0.33 h

7.1: 2.70 g / MgSO₄ / benzene / 1 h / Heating

8.1: 79 percent / potassium carbonate; DMAP / dimethylformamide; H₂O / 48 h / 20 °C

9.1: 95 percent / triethylamine / Pd(OAc)2 / 48 h / 70 °C / 20520 Torr

With dmap; n-butyllithium; tetrabutyl ammonium fluoride; tert.-butyl lithium; magnesium sulfate; potassium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; sodium iodide; palladium diacetate; In tetrahydrofuran; hexane; chloroform; water; N,N-dimethyl-formamide; acetone; pentane; benzene;
DOI:10.1021/jo026595t