7-benzyloxy-1-ethyl-3,3,5-trimethyl-1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione

Base Information

Chemical Name:7-benzyloxy-1-ethyl-3,3,5-trimethyl-1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione
CAS No.:1266246-90-5
Molecular Formula:C₂₁H₂₄N₂O₃
Molecular Weight:352.433
Hs Code.:

Synonyms:7-benzyloxy-1-ethyl-3,3,5-trimethyl-1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 7-benzyloxy-1-ethyl-3,3,5-trimethyl-1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione

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Technology Process of 7-benzyloxy-1-ethyl-3,3,5-trimethyl-1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione

There total 7 articles about 7-benzyloxy-1-ethyl-3,3,5-trimethyl-1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1266246-89-2
7-benzyloxy-1-ethyl-5-methyl-1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione

: 74-88-4
methyl iodide

: 1266246-90-5
7-benzyloxy-1-ethyl-3,3,5-trimethyl-1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione

Guidance literature:: 7-benzyloxy-1-ethyl-5-methyl-1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione; With sodium hydride; In N,N-dimethyl-formamide; oil; at 0 ℃;

methyl iodide; In N,N-dimethyl-formamide; oil; at 0 ℃;

Reference yield: 91.0%

: 1266246-95-0
8-benzyloxy-1,3,3-trimethyl-1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione

: 75-03-6
ethyl iodide

: 1266246-90-5
7-benzyloxy-1-ethyl-3,3,5-trimethyl-1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione

Guidance literature:: 8-benzyloxy-1,3,3-trimethyl-1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione; With sodium t-butanolate; In N,N-dimethyl acetamide; for 0.5h; Cooling with ice;

ethyl iodide; at 10 - 20 ℃; for 4h;

Reference yield:

: 120381-42-2
4-fluoro-2-methylaminonitrobenzene

: 1266246-90-5
7-benzyloxy-1-ethyl-3,3,5-trimethyl-1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate; tetrabutyl-ammonium chloride / toluene / 3.5 h / Reflux

2.1: hydrogen / platinum on carbon / toluene; water / 3040.2 Torr

2.2: 0.5 h / Cooling with ice

3.1: N,N-dimethyl acetamide / 2.5 h / Cooling with ice

4.1: sodium t-butanolate / N,N-dimethyl acetamide / 0.5 h / Cooling with ice

4.2: 4 h / 10 - 20 °C

With tetrabutyl-ammonium chloride; hydrogen; potassium carbonate; sodium t-butanolate; platinum on carbon; In N,N-dimethyl acetamide; water; toluene;