4-(iodomethyl)-3-(2-methylpropylidene)-1-(phenylmethoxy)-2-pyrrolidinone

Base Information

Chemical Name:4-(iodomethyl)-3-(2-methylpropylidene)-1-(phenylmethoxy)-2-pyrrolidinone
CAS No.:1373213-69-4
Molecular Formula:C₁₆H₂₀INO₂
Molecular Weight:385.245
Hs Code.:

Synonyms:4-(iodomethyl)-3-(2-methylpropylidene)-1-(phenylmethoxy)-2-pyrrolidinone

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Chemical Property of 4-(iodomethyl)-3-(2-methylpropylidene)-1-(phenylmethoxy)-2-pyrrolidinone

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Technology Process of 4-(iodomethyl)-3-(2-methylpropylidene)-1-(phenylmethoxy)-2-pyrrolidinone

There total 5 articles about 4-(iodomethyl)-3-(2-methylpropylidene)-1-(phenylmethoxy)-2-pyrrolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 75-30-9
2-iodo-propane

: 1373213-74-1
C₁₃H₁₃NO₂

: 1373213-84-3
2-iodo-4-methyl-N-(phenylmethoxy)-N-(2-propen-1-yl)-2-pentenamide

: 1373213-69-4
4-(iodomethyl)-3-(2-methylpropylidene)-1-(phenylmethoxy)-2-pyrrolidinone

Guidance literature:: C₁₃H₁₃NO₂; With (3aR,3a’R,8aS,8a’S)-2,2’-(cyclopropane-1,1-diyl)bis(3a,8a-dihydro-8H-indeno[1,2-d]-oxazole); zinc trifluoromethanesulfonate; In dichloromethane; at 20 ℃; for 0.5h; Inert atmosphere;

2-iodo-propane; With triethyl borane; In hexane; dichloromethane; at -78 ℃; Inert atmosphere;
DOI:10.1039/c2ob25073j

Reference yield:

: 122149-19-3
N-allyl-O-benzylhydroxylamine

: 1373213-84-3
2-iodo-4-methyl-N-(phenylmethoxy)-N-(2-propen-1-yl)-2-pentenamide

: 1373213-69-4
4-(iodomethyl)-3-(2-methylpropylidene)-1-(phenylmethoxy)-2-pyrrolidinone

Guidance literature:: Multi-step reaction with 2 steps

1.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 3 h / 20 °C / Inert atmosphere

2.1: (3aR,3a’R,8aS,8a’S)-2,2’-(cyclopropane-1,1-diyl)bis(3a,8a-dihydro-8H-indeno[1,2-d]-oxazole); zinc trifluoromethanesulfonate / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

2.2: -78 °C / Inert atmosphere

With dmap; (3aR,3a’R,8aS,8a’S)-2,2’-(cyclopropane-1,1-diyl)bis(3a,8a-dihydro-8H-indeno[1,2-d]-oxazole); zinc trifluoromethanesulfonate; dicyclohexyl-carbodiimide; In dichloromethane;
DOI:10.1039/c2ob25073j

Reference yield:

: 122148-92-9
N-(phenylmethoxy)-N-2-propenylcarbamic acid 1,1-dimethylethyl ester

: 1373213-84-3
2-iodo-4-methyl-N-(phenylmethoxy)-N-(2-propen-1-yl)-2-pentenamide

: 1373213-69-4
4-(iodomethyl)-3-(2-methylpropylidene)-1-(phenylmethoxy)-2-pyrrolidinone

Guidance literature:: Multi-step reaction with 3 steps

1.1: trifluoroacetic acid / dichloromethane / 5 h / 0 - 20 °C / Inert atmosphere

2.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 3 h / 20 °C / Inert atmosphere

3.1: (3aR,3a’R,8aS,8a’S)-2,2’-(cyclopropane-1,1-diyl)bis(3a,8a-dihydro-8H-indeno[1,2-d]-oxazole); zinc trifluoromethanesulfonate / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

3.2: -78 °C / Inert atmosphere

With dmap; (3aR,3a’R,8aS,8a’S)-2,2’-(cyclopropane-1,1-diyl)bis(3a,8a-dihydro-8H-indeno[1,2-d]-oxazole); zinc trifluoromethanesulfonate; dicyclohexyl-carbodiimide; trifluoroacetic acid; In dichloromethane;
DOI:10.1039/c2ob25073j