(E)-2,3-Bis-(4-methoxy-phenyl)-acrylic acid methyl ester

Base Information

Chemical Name:(E)-2,3-Bis-(4-methoxy-phenyl)-acrylic acid methyl ester
CAS No.:50415-62-8
Molecular Formula:C₁₈H₁₈O₄
Molecular Weight:298.339
Hs Code.:
DSSTox Substance ID:DTXSID401163772
ChEMBL ID:CHEMBL78486

Synonyms:CHEMBL78486;DTXSID401163772;BDBM50145701;methyl (2e)-2,3-bis(4-methoxyphenyl)acrylate;(E)-2,3-Bis-(4-methoxy-phenyl)-acrylic acid methyl ester;Methyl (alphaE)-4-methoxy-alpha-[(4-methoxyphenyl)methylene]benzeneacetate;50415-62-8

Suppliers and Price of (E)-2,3-Bis-(4-methoxy-phenyl)-acrylic acid methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-2,3-Bis-(4-methoxy-phenyl)-acrylic acid methyl ester

Chemical Property:

XLogP3:3.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:298.12050905
Heavy Atom Count:22
Complexity:375

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=CC=C(C=C1)C=C(C2=CC=C(C=C2)OC)C(=O)OC
Isomeric SMILES:COC1=CC=C(C=C1)/C=C(\C2=CC=C(C=C2)OC)/C(=O)OC

Technology Process of (E)-2,3-Bis-(4-methoxy-phenyl)-acrylic acid methyl ester

There total 8 articles about (E)-2,3-Bis-(4-methoxy-phenyl)-acrylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 32383-67-8,83072-25-7,32383-66-7
(E)-2,3-bis(4-methoxyphenyl)acrylic acid

: 74-88-4
methyl iodide

: 50415-62-8,693775-75-6
methyl (E)-4-methoxy-α-(4'-methoxyphenylmethylene)benzeneacetate

Guidance literature:: (E)-2,3-bis(4-methoxyphenyl)acrylic acid; With potassium hydroxide; In dimethyl sulfoxide; for 1h; Inert atmosphere;

methyl iodide; In dimethyl sulfoxide; for 1h; Inert atmosphere;
DOI:10.1002/anie.201006292

Reference yield: 62.0%

: 67-56-1
methanol

: 32383-67-8,83072-25-7,32383-66-7
(E)-2,3-bis(4-methoxyphenyl)acrylic acid

: 50415-62-8,693775-75-6
methyl (E)-4-methoxy-α-(4'-methoxyphenylmethylene)benzeneacetate

Guidance literature:: With hydrogenchloride; for 20h; Heating;
DOI:10.1021/jm0498708

Reference yield:

: 104-01-8
4-Methoxyphenylacetic acid

: 50415-62-8,693775-75-6
methyl (E)-4-methoxy-α-(4'-methoxyphenylmethylene)benzeneacetate

Guidance literature:: Multi-step reaction with 2 steps

1: 60 percent / triethylamine; acetic anhydride / 12 h / 140 °C

2: 62 percent / HCl / 20 h / Heating

With hydrogenchloride; acetic anhydride; triethylamine;
DOI:10.1021/jm0498708