2-(2,3-dimethoxybenzyl)-7-fluoro-2,3-dihydro-thieno[2,3-b]thiochromen-4-one

Base Information

• Chemical Name: 2-(2,3-dimethoxybenzyl)-7-fluoro-2,3-dihydro-thieno[2,3-b]thiochromen-4-one
• CAS No.: 1246017-03-7
• Molecular Formula: C₂₀H₁₇FO₃S₂
• Molecular Weight: 388.484

Synonyms:2-(2,3-dimethoxybenzyl)-7-fluoro-2,3-dihydro-thieno[2,3-b]thiochromen-4-one

Chemical Property of 2-(2,3-dimethoxybenzyl)-7-fluoro-2,3-dihydro-thieno[2,3-b]thiochromen-4-one

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Technology Process of 2-(2,3-dimethoxybenzyl)-7-fluoro-2,3-dihydro-thieno[2,3-b]thiochromen-4-one

There total 1 articles about 2-(2,3-dimethoxybenzyl)-7-fluoro-2,3-dihydro-thieno[2,3-b]thiochromen-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

S-(5-(2,4-difluorophenyl)-1-(2,3-dimethoxyphenyl)-5-oxopentan-2-yl) O-ethyl carbonodithioate (1246016-72-7) → 2-(2,3-dimethoxybenzyl)-7-fluoro-2,3-dihydro-thieno[2,3-b]thiochromen-4-one (1246017-03-7)

Guidance literature:

With potassium carbonate; In acetonitrile; tert-butyl alcohol; for 3.5h; Inert atmosphere; Reflux;

DOI:10.1016/j.tetasy.2010.06.006

Reference yield: 96.0%

methanol (67-56-1) + 2-(2,3-dimethoxybenzyl)-7-fluoro-2,3-dihydro-thieno[2,3-b]thiochromen-4-one (1246017-03-7) → 2-(2,3-dimethoxybenzyl)-7-methoxy-2,3-dihydro-thieno[2,3-b][1]benzothiopyran-4-one (1246017-07-1)

Guidance literature:

With sodium tetrahydroborate; In tetrahydrofuran; at 90 - 100 ℃; for 1.5h; Inert atmosphere;

DOI:10.1016/j.tetasy.2010.06.006

Reference yield: 73.0%

2,2,2-trifluoroethanol (75-89-8) + 2-(2,3-dimethoxybenzyl)-7-fluoro-2,3-dihydro-thieno[2,3-b]thiochromen-4-one (1246017-03-7) → 2-(2,3-dimethoxybenzyl)-7-(2,2,2-trifluoroethoxy)-2,3-dihydro-thieno[2,3-b][1]benzothiopyran-4-one (1246017-08-2)

Guidance literature:

With potassium carbonate; at 100 ℃; for 1h; Inert atmosphere;

DOI:10.1016/j.tetasy.2010.06.006

upstream raw materials:

S-(5-(2,4-difluorophenyl)-1-(2,3-dimethoxyphenyl)-5-oxopentan-2-yl) O-ethyl carbonodithioate

Downstream raw materials:

2-(2,3-dimethoxybenzyl)-7-(morpholin-4-yl)-2,3-dihydro-thieno[2,3-b][1]benzothiopyran-4-one

2-(2,3-dimethoxybenzyl)-7-methoxy-2,3-dihydro-thieno[2,3-b][1]benzothiopyran-4-one

2-(2,3-dimethoxybenzyl)-7-(2,2,2-trifluoroethoxy)-2,3-dihydro-thieno[2,3-b][1]benzothiopyran-4-one

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