9H-fluoren-9-ylmethyl (6-{[2-({2-[3-({[4-(aminomethyl)phenyl]sulfonyl}amino)-3-oxopropyl]phenyl}amino)-2-oxoethyl]amino}-6-oxohexyl)carbamate

Base Information

Chemical Name:9H-fluoren-9-ylmethyl (6-{[2-({2-[3-({[4-(aminomethyl)phenyl]sulfonyl}amino)-3-oxopropyl]phenyl}amino)-2-oxoethyl]amino}-6-oxohexyl)carbamate
CAS No.:1609106-34-4
Molecular Formula:C₃₉H₄₃N₅O₇S
Molecular Weight:725.866
Hs Code.:

Synonyms:9H-fluoren-9-ylmethyl (6-{[2-({2-[3-({[4-(aminomethyl)phenyl]sulfonyl}amino)-3-oxopropyl]phenyl}amino)-2-oxoethyl]amino}-6-oxohexyl)carbamate

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Chemical Property of 9H-fluoren-9-ylmethyl (6-{[2-({2-[3-({[4-(aminomethyl)phenyl]sulfonyl}amino)-3-oxopropyl]phenyl}amino)-2-oxoethyl]amino}-6-oxohexyl)carbamate

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Technology Process of 9H-fluoren-9-ylmethyl (6-{[2-({2-[3-({[4-(aminomethyl)phenyl]sulfonyl}amino)-3-oxopropyl]phenyl}amino)-2-oxoethyl]amino}-6-oxohexyl)carbamate

There total 10 articles about 9H-fluoren-9-ylmethyl (6-{[2-({2-[3-({[4-(aminomethyl)phenyl]sulfonyl}amino)-3-oxopropyl]phenyl}amino)-2-oxoethyl]amino}-6-oxohexyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1609106-33-3
9H-fluoren-9-ylmethyl{6-[(2-{[2-(3-{[(4-{[(tert-butoxycarbonyl)amino]methyl}phenyl)sulfonyl]amino}-3-oxopropyl)phenyl]amino}-2-oxoethyl)amino]-6-oxohexyl}carbamate

: 1609106-34-4
9H-fluoren-9-ylmethyl (6-{[2-({2-[3-({[4-(aminomethyl)phenyl]sulfonyl}amino)-3-oxopropyl]phenyl}amino)-2-oxoethyl]amino}-6-oxohexyl)carbamate

Guidance literature:: With trifluoroacetic acid; In dichloromethane; for 2h;

Reference yield:

: 88574-06-5
6-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}hexanoic acid

: 1609106-34-4
9H-fluoren-9-ylmethyl (6-{[2-({2-[3-({[4-(aminomethyl)phenyl]sulfonyl}amino)-3-oxopropyl]phenyl}amino)-2-oxoethyl]amino}-6-oxohexyl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: dicyclohexyl-carbodiimide / tetrahydrofuran / 0 - 20 °C

2: sodium hydrogencarbonate / tetrahydrofuran; water; 1,2-dimethoxyethane / 16 h / 20 °C

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 3.5 h / 20 °C

4: trifluoroacetic acid / dichloromethane / 2 h

With dmap; sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water;

Reference yield:

: 88939-75-7
methyl (2E)-3-(2-aminophenyl)propenoate

: 1609106-34-4
9H-fluoren-9-ylmethyl (6-{[2-({2-[3-({[4-(aminomethyl)phenyl]sulfonyl}amino)-3-oxopropyl]phenyl}amino)-2-oxoethyl]amino}-6-oxohexyl)carbamate

Guidance literature:: Multi-step reaction with 7 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; dmap / N,N-dimethyl-formamide / 18 h / 20 - 50 °C

2: palladium on activated charcoal; hydrogen / methanol; ethyl acetate / 9 h / 20 °C / 1551.49 Torr

3: water; sodium hydroxide / tetrahydrofuran / 3 h / 20 °C

4: hydrogenchloride / 1,4-dioxane / 3 h / 20 °C

5: sodium hydrogencarbonate / tetrahydrofuran; water; 1,2-dimethoxyethane / 16 h / 20 °C

6: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 3.5 h / 20 °C

7: trifluoroacetic acid / dichloromethane / 2 h

With hydrogenchloride; dmap; palladium on activated charcoal; water; hydrogen; sodium hydrogencarbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;