Methyl 3-{4-[2-(2-hydroxy-3,6-dimethoxyphenyl)ethyl]phenoxy}-4-methoxybenzoate

Base Information

Chemical Name:Methyl 3-{4-[2-(2-hydroxy-3,6-dimethoxyphenyl)ethyl]phenoxy}-4-methoxybenzoate
CAS No.:308804-96-8
Molecular Formula:C₂₅H₂₆O₇
Molecular Weight:438.477
Hs Code.:

Synonyms:Methyl 3-{4-[2-(2-hydroxy-3,6-dimethoxyphenyl)ethyl]phenoxy}-4-methoxybenzoate

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Chemical Property of Methyl 3-{4-[2-(2-hydroxy-3,6-dimethoxyphenyl)ethyl]phenoxy}-4-methoxybenzoate

Chemical Property:

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Technology Process of Methyl 3-{4-[2-(2-hydroxy-3,6-dimethoxyphenyl)ethyl]phenoxy}-4-methoxybenzoate

There total 7 articles about Methyl 3-{4-[2-(2-hydroxy-3,6-dimethoxyphenyl)ethyl]phenoxy}-4-methoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 308804-94-6
Methyl 3-{4-[(E)-2-(2-benzyloxy-3,6-dimethoxyphenyl)-1-ethenyl]phenoxy}-4-methoxybenzoate

: 308804-96-8
Methyl 3-{4-[2-(2-hydroxy-3,6-dimethoxyphenyl)ethyl]phenoxy}-4-methoxybenzoate

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate; at 20 ℃; for 24h; under 2250.18 - 3750.3 Torr;
DOI:10.1055/s-2000-7106

Reference yield:

: 64466-51-9
3,6-Dimethoxy-2-hydroxybenzaldehyde

: 308804-96-8
Methyl 3-{4-[2-(2-hydroxy-3,6-dimethoxyphenyl)ethyl]phenoxy}-4-methoxybenzoate

Guidance literature:: Multi-step reaction with 3 steps

1: 60 percent / K₂CO₃ / methanol / Heating

2: 76 percent / K₂CO₃; 18-crown-6 / toluene / 24 h / Heating

3: 84 percent / H₂ / 5 percent Pd/C / ethyl acetate / 24 h / 20 °C / 2250.18 - 3750.3 Torr

With 18-crown-6 ether; hydrogen; potassium carbonate; palladium on activated charcoal; In methanol; ethyl acetate; toluene; 1: Etherification / 2: Condensation / 3: Hydrogenation;
DOI:10.1055/s-2000-7106

Reference yield:

: 135303-87-6
methyl 3-(4'-formylphenoxy)-4-methoxybenzoate

: 308804-96-8
Methyl 3-{4-[2-(2-hydroxy-3,6-dimethoxyphenyl)ethyl]phenoxy}-4-methoxybenzoate

Guidance literature:: Multi-step reaction with 5 steps

1: 100 percent / NaBH₄ / methanol / 20 °C

2: 91 percent / SOCl₂; pyridine / diethyl ether / 4 h / Heating

3: 85 percent / toluene / 24 h / Heating

4: 76 percent / K₂CO₃; 18-crown-6 / toluene / 24 h / Heating

5: 84 percent / H₂ / 5 percent Pd/C / ethyl acetate / 24 h / 20 °C / 2250.18 - 3750.3 Torr

With pyridine; sodium tetrahydroborate; thionyl chloride; 18-crown-6 ether; hydrogen; potassium carbonate; palladium on activated charcoal; In methanol; diethyl ether; ethyl acetate; toluene; 1: Reduction / 2: Substitution / 3: Substitution / 4: Condensation / 5: Hydrogenation;
DOI:10.1055/s-2000-7106