4-nitrophenyl tetrahydro-2H-pyran-4-ylcarbamate

Base Information

• Chemical Name: 4-nitrophenyl tetrahydro-2H-pyran-4-ylcarbamate
• CAS No.: 932114-22-2
• Molecular Formula: C₁₂H₁₄N₂O₅
• Molecular Weight: 266.254
• Mol file: 932114-22-2.mol

Synonyms:4-nitrophenyl tetrahydro-2H-pyran-4-ylcarbamate

Chemical Property of 4-nitrophenyl tetrahydro-2H-pyran-4-ylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 4-nitrophenyl tetrahydro-2H-pyran-4-ylcarbamate

There total 2 articles about 4-nitrophenyl tetrahydro-2H-pyran-4-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-aminotetrahydropyran (38041-19-9) + 4-Nitrophenyl chloroformate (7693-46-1) → 4-nitrophenyl tetrahydro-2H-pyran-4-ylcarbamate (932114-22-2)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 18h;

Reference yield:

tetrahydro-2H-pyran-4-ylamine monohydrochloride (33024-60-1) + 4-Nitrophenyl chloroformate (7693-46-1) → 4-nitrophenyl tetrahydro-2H-pyran-4-ylcarbamate (932114-22-2)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at -15 - 0 ℃; for 2h;

Reference yield:

4-nitrophenyl tetrahydro-2H-pyran-4-ylcarbamate (932114-22-2) + 6-chloro-7-(3-cyanophenyl)-1,2,3,4-tetrahydro-pyrrolo[1,2-a]pyrazine-8-carboxamide (1352087-33-2) → 6-chloro-7-(3-cyanophenyl)-N2-(tetrahydro-2H-pyran-4-yl)-3,4-dihydropyrrolo[1,2-a]pyrazine-2,8(1H)-dicarboxamide (1352087-00-3)

Guidance literature:

With potassium carbonate; In acetonitrile; at 65 ℃; for 1.5h;

upstream raw materials:

4-aminotetrahydropyran

4-Nitrophenyl chloroformate

tetrahydro-2H-pyran-4-ylamine monohydrochloride

Downstream raw materials:

6-chloro-7-(3-cyanophenyl)-N²-(tetrahydro-2H-pyran-4-yl)-3,4-dihydropyrrolo[1,2-a]pyrazine-2,8(1H)-dicarboxamide

Refernces

• 1、 -. "3,4-DIHYDROPYRROLO[1,2-A]PYRAZINE-2,8(1H)-DICARBOXAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF". Page/Page column 67. . Retrieved 2012/01/13.
• 2、 -. "PYRAZOLO[3,4-B]PYRIDINE COMPOUNDS, AND THEIR USE AS PDE4 INHIBITORS". Page/Page column 205-206. . Retrieved 2010/11/26.