(1R,2R)-2-[(dichloroacetyl)amino]-1-(4-nitrophenyl)-3-(propanoyloxy)propyl propanoate

Base Information

Chemical Name:(1R,2R)-2-[(dichloroacetyl)amino]-1-(4-nitrophenyl)-3-(propanoyloxy)propyl propanoate
CAS No.:1304534-01-7
Molecular Formula:C₁₇H₂₀Cl₂N₂O₇
Molecular Weight:435.261
Hs Code.:

Synonyms:(1R,2R)-2-[(dichloroacetyl)amino]-1-(4-nitrophenyl)-3-(propanoyloxy)propyl propanoate

Suppliers and Price of (1R,2R)-2-[(dichloroacetyl)amino]-1-(4-nitrophenyl)-3-(propanoyloxy)propyl propanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1R,2R)-2-[(dichloroacetyl)amino]-1-(4-nitrophenyl)-3-(propanoyloxy)propyl propanoate

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Technology Process of (1R,2R)-2-[(dichloroacetyl)amino]-1-(4-nitrophenyl)-3-(propanoyloxy)propyl propanoate

There total 3 articles about (1R,2R)-2-[(dichloroacetyl)amino]-1-(4-nitrophenyl)-3-(propanoyloxy)propyl propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 56-75-7,85666-84-8
chloramphenicol

: 79-03-8
propionyl chloride

: 1304534-01-7
(1R,2R)-2-[(dichloroacetyl)amino]-1-(4-nitrophenyl)-3-(propanoyloxy)propyl propanoate

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;
DOI:10.1016/j.tet.2011.02.070

Reference yield: 85.0%

: 56-75-7,85666-84-8
chloramphenicol

: 123-62-6
propionic acid anhydride

: 1304534-01-7
(1R,2R)-2-[(dichloroacetyl)amino]-1-(4-nitrophenyl)-3-(propanoyloxy)propyl propanoate

: 33987-21-2
(2R,3R)-2-[(dichloroacetyl)amino]-3-hydroxy-3-(4-nitrophenyl)propyl propionate

Guidance literature:: With pyridine; dmap; In dichloromethane; for 0.0833333h;
DOI:10.1021/acs.jnatprod.7b00903

Reference yield:

: 10318-17-9
(1R,2R)-3-(acetyloxy)-2-[(dichloroacetyl)amino]-1-(4-nitrophenyl)propyl acetate

: 1304534-01-7
(1R,2R)-2-[(dichloroacetyl)amino]-1-(4-nitrophenyl)-3-(propanoyloxy)propyl propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: Novozym 435 / acetonitrile / 24 h / 20 °C / pH 7 / aq. phosphate buffer; Enzymatic reaction

2: dmap; triethylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere

With dmap; triethylamine; In dichloromethane; acetonitrile;
DOI:10.1016/j.tet.2011.02.070