1-(4-chlorophenyl)-4-((dimethylamino)methyl)-3-methyl-1H-pyrazol-5(4H)-one

Base Information

• Chemical Name: 1-(4-chlorophenyl)-4-((dimethylamino)methyl)-3-methyl-1H-pyrazol-5(4H)-one
• CAS No.: 1498334-96-5
• Molecular Formula: C₁₃H₁₆ClN₃O
• Molecular Weight: 265.743
• Mol file: 1498334-96-5.mol

Synonyms:1-(4-chlorophenyl)-4-((dimethylamino)methyl)-3-methyl-1H-pyrazol-5(4H)-one

Chemical Property of 1-(4-chlorophenyl)-4-((dimethylamino)methyl)-3-methyl-1H-pyrazol-5(4H)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(4-chlorophenyl)-4-((dimethylamino)methyl)-3-methyl-1H-pyrazol-5(4H)-one

There total 2 articles about 1-(4-chlorophenyl)-4-((dimethylamino)methyl)-3-methyl-1H-pyrazol-5(4H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + N,N-dimethylammonium chloride (506-59-2) + 1-(4-chlorophenyl)-3-methyl-2-pyrazolin-5-one (13024-90-3) → 1-(4-chlorophenyl)-4-((dimethylamino)methyl)-3-methyl-1H-pyrazol-5(4H)-one (1498334-96-5)

Guidance literature:

formaldehyd; N,N-dimethylammonium chloride; at 20 ℃; for 0.5h;

With acetic anhydride; at 70 - 90 ℃;

1-(4-chlorophenyl)-3-methyl-2-pyrazolin-5-one; at 70 - 75 ℃; for 12h;

DOI:10.1248/cpb.c13-00314

Reference yield:

4-chlorophenylhydrazine hydrochloride (1073-70-7) → 1-(4-chlorophenyl)-4-((dimethylamino)methyl)-3-methyl-1H-pyrazol-5(4H)-one (1498334-96-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium acetate; acetic acid / 24 h / 20 °C

2.1: 0.5 h / 20 °C

2.2: 70 - 90 °C

2.3: 12 h / 70 - 75 °C

With sodium acetate; acetic acid; 2.1: |Mannich Aminomethylation / 2.2: |Mannich Aminomethylation / 2.3: |Mannich Aminomethylation;

DOI:10.1248/cpb.c13-00314

Reference yield:

1-(4-chlorophenyl)-4-((dimethylamino)methyl)-3-methyl-1H-pyrazol-5(4H)-one (1498334-96-5) + methyl iodide (74-88-4) → C14H19ClN3O(1+)*I(1-)

Guidance literature:

In acetone; at 5 - 20 ℃;

DOI:10.1248/cpb.c13-00314

upstream raw materials:

formaldehyd

N,N-dimethylammonium chloride

1-(4-chlorophenyl)-3-methyl-2-pyrazolin-5-one

4-chlorophenylhydrazine hydrochloride

Downstream raw materials:

2-(1-(4-chlorophenyl)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-4-yl) acetonitrile

methyl 2-(1-(4-chlorophenyl)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-4-yl)acetate