4-(2-Chloro-phenyl)-2-(2,3-dihydro-benzofuran-5-ylethynyl)-9-methyl-6H-1-thia-5,7,8,9a-tetraaza-cyclopenta[e]azulene

Base Information

Chemical Name:4-(2-Chloro-phenyl)-2-(2,3-dihydro-benzofuran-5-ylethynyl)-9-methyl-6H-1-thia-5,7,8,9a-tetraaza-cyclopenta[e]azulene
CAS No.:132464-69-8
Molecular Formula:C₂₅H₁₇ClN₄OS
Molecular Weight:456.955
Hs Code.:

Synonyms:4-(2-Chloro-phenyl)-2-(2,3-dihydro-benzofuran-5-ylethynyl)-9-methyl-6H-1-thia-5,7,8,9a-tetraaza-cyclopenta[e]azulene

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Chemical Property of 4-(2-Chloro-phenyl)-2-(2,3-dihydro-benzofuran-5-ylethynyl)-9-methyl-6H-1-thia-5,7,8,9a-tetraaza-cyclopenta[e]azulene

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Technology Process of 4-(2-Chloro-phenyl)-2-(2,3-dihydro-benzofuran-5-ylethynyl)-9-methyl-6H-1-thia-5,7,8,9a-tetraaza-cyclopenta[e]azulene

There total 4 articles about 4-(2-Chloro-phenyl)-2-(2,3-dihydro-benzofuran-5-ylethynyl)-9-methyl-6H-1-thia-5,7,8,9a-tetraaza-cyclopenta[e]azulene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 67860-41-7
4-(2-chlorophenyl)2-iodo-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine

: 132464-87-0
5-ethynyl-2,3-dihydrobenzofuran

: 132464-69-8
4-(2-Chloro-phenyl)-2-(2,3-dihydro-benzofuran-5-ylethynyl)-9-methyl-6H-1-thia-5,7,8,9a-tetraaza-cyclopenta[e]azulene

Guidance literature:: With copper(l) iodide; palladium diacetate; triethylamine; triphenylphosphine; In N,N-dimethyl-formamide; for 5h;
DOI:10.1021/jm00108a031

Reference yield:

: 496-16-2
2.3-dihydrobenzofuran

: 132464-69-8
4-(2-Chloro-phenyl)-2-(2,3-dihydro-benzofuran-5-ylethynyl)-9-methyl-6H-1-thia-5,7,8,9a-tetraaza-cyclopenta[e]azulene

Guidance literature:: Multi-step reaction with 4 steps

1: 76 percent / ICl / acetic acid / 0.25 h / Ambient temperature

2: Ph₃P, CuI, Et₃N, palladium acetate / acetonitrile / 2 h / Ambient temperature

3: K₂CO₃ / methanol / 2 h / Ambient temperature

4: 39 percent / Ph₃P, CuI, Et₃N, palladium acetate / dimethylformamide / 5 h

With copper(l) iodide; palladium diacetate; Iodine monochloride; potassium carbonate; triethylamine; triphenylphosphine; In methanol; acetic acid; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm00108a031

Reference yield:

: 132464-84-7
5-iodo-2,3-dihydrobenzo[b]furan

: 132464-69-8
4-(2-Chloro-phenyl)-2-(2,3-dihydro-benzofuran-5-ylethynyl)-9-methyl-6H-1-thia-5,7,8,9a-tetraaza-cyclopenta[e]azulene

Guidance literature:: Multi-step reaction with 3 steps

1: Ph₃P, CuI, Et₃N, palladium acetate / acetonitrile / 2 h / Ambient temperature

2: K₂CO₃ / methanol / 2 h / Ambient temperature

3: 39 percent / Ph₃P, CuI, Et₃N, palladium acetate / dimethylformamide / 5 h

With copper(l) iodide; palladium diacetate; potassium carbonate; triethylamine; triphenylphosphine; In methanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm00108a031