2-Cyano-5-methoxypyridine

Base Information

• Chemical Name: 2-Cyano-5-methoxypyridine
• CAS No.: 89809-63-2
• Molecular Formula: C7H6 N2 O
• Molecular Weight: 134.137
• Hs Code.: 2933399090
• Mol file: 89809-63-2.mol

Synonyms:2-Cyano-5-methoxypyridine;5-Methoxy-2-pyridinecarbonitrile

Chemical Property of 2-Cyano-5-methoxypyridine

Chemical Property:

• Vapor Pressure: 0.0037mmHg at 25°C
• Refractive Index: 1.521
• Boiling Point: 280.8oC at 760 mmHg
• PKA: -4.06±0.10(Predicted)
• Flash Point: 123.6oC
• PSA: 45.91000
• Density: 1.115g/cm3
• LogP: 0.96188
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

2-Cyano-5-methoxypyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Cyano-5-methoxypyridine

There total 7 articles about 2-Cyano-5-methoxypyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

5-hydroxypyridine-2-carbonitrile + methyl iodide (74-88-4) → 5-methoxypyridine-2-carbonitrile (89809-63-2)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 24h;

Reference yield: 42.0%

zinc(II) cyanide (557-21-1) + 2-chloro-5-methoxypyridine (139585-48-1) → 5-methoxypyridine-2-carbonitrile (89809-63-2)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 90 ℃; for 16h;

DOI:10.1021/jm401625b

Reference yield:

3-methoxypyridine N-oxide (14906-61-7) + trimethylsilyl cyanide (7677-24-9) → 3-methoxy-pyridine-2-carbonitrile (24059-89-0) + 5-methoxypyridine-2-carbonitrile (89809-63-2)

Guidance literature:

With N,N-Dimethylcarbamoyl chloride; In dichloromethane; Yield given. Yields of byproduct given; Ambient temperature;

upstream raw materials:

3-methoxypyridine N-oxide

trimethylsilyl cyanide

5-fluoropicolinonitrile

methyl iodide

Downstream raw materials:

5-methoxypyrid-2-ylamidoxime

5-methoxypyridine-2-carboxylic acid

Refernces

• 1、 Qin, Yangzhong,Martindale, Benjamin C. M.,Sun, Rui,Rieth, Adam J.,Nocera, Daniel G.. "Solar-driven tandem photoredox nickel-catalysed cross-coupling using modified carbon nitride". . p. 7456 - 7461. Retrieved 2020/08/03.
• 2、 He, Gang,Zhang, Shu-Yu,Nack, William A.,Li, Qiong,Chen, Gong. "Use of a readily removable auxiliary group for the synthesis of pyrrolidones by the palladium-catalyzed intramolecular amination of unactivated γ C(sp3)-H Bonds". supporting information. p. 11124 - 11128. Retrieved 2013/10/22.