4-(tert-butyl-dimethyl-silyloxy)-1-(1'-nitro-4',4'-diphenylcyclohexyl)-butan-1-ol

Base Information

Chemical Name:4-(tert-butyl-dimethyl-silyloxy)-1-(1'-nitro-4',4'-diphenylcyclohexyl)-butan-1-ol
CAS No.:615268-47-8
Molecular Formula:C₂₈H₄₁NO₄Si
Molecular Weight:483.723
Hs Code.:

Synonyms:4-(tert-butyl-dimethyl-silyloxy)-1-(1'-nitro-4',4'-diphenylcyclohexyl)-butan-1-ol

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Chemical Property of 4-(tert-butyl-dimethyl-silyloxy)-1-(1'-nitro-4',4'-diphenylcyclohexyl)-butan-1-ol

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Technology Process of 4-(tert-butyl-dimethyl-silyloxy)-1-(1'-nitro-4',4'-diphenylcyclohexyl)-butan-1-ol

There total 4 articles about 4-(tert-butyl-dimethyl-silyloxy)-1-(1'-nitro-4',4'-diphenylcyclohexyl)-butan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 87184-81-4
4-(tert-butyldimethylsilanyloxy)butanal

: 615268-46-7
1-nitro-4,4-diphenylcyclohexane

: 615268-47-8
4-(tert-butyl-dimethyl-silyloxy)-1-(1'-nitro-4',4'-diphenylcyclohexyl)-butan-1-ol

Guidance literature:: With sodium hydroxide; cetyl ammonium bromide; In tetrahydrofuran; at 20 ℃; for 12h;
DOI:10.1021/ol035564x

Reference yield:

: 35380-17-7
4,4-diphenylcyclohexanone oxime

: 615268-47-8
4-(tert-butyl-dimethyl-silyloxy)-1-(1'-nitro-4',4'-diphenylcyclohexyl)-butan-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1: 28 percent / trichloroisocyanuric acid; NaHCO₃ / H₂O; ethyl acetate / 24 h / 20 °C

2: 48 percent / NaBH₄ / Pd/C / ethanol / 1 h / 20 °C

3: 50 percent / NaOH; cetyl ammonium bromide / tetrahydrofuran; H₂O / 12 h / 20 °C

With sodium hydroxide; sodium tetrahydroborate; trichloroisocyanuric acid; cetyl ammonium bromide; sodium hydrogencarbonate; palladium on activated charcoal; In tetrahydrofuran; ethanol; water; ethyl acetate; 3: Henry reaction;
DOI:10.1016/j.tet.2006.03.063

Reference yield:

: 4528-68-1
4,4-diphenylcyclohexan-1-one

: 615268-47-8
4-(tert-butyl-dimethyl-silyloxy)-1-(1'-nitro-4',4'-diphenylcyclohexyl)-butan-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 97 percent / hydroxylamine hydrochloride; sodium acetate / ethanol; H₂O / 2 h / 20 °C

2: 28 percent / trichloroisocyanuric acid; NaHCO₃ / H₂O; ethyl acetate / 24 h / 20 °C

3: 48 percent / NaBH₄ / Pd/C / ethanol / 1 h / 20 °C

4: 50 percent / NaOH; cetyl ammonium bromide / tetrahydrofuran; H₂O / 12 h / 20 °C

With sodium hydroxide; sodium tetrahydroborate; trichloroisocyanuric acid; hydroxylamine hydrochloride; sodium acetate; cetyl ammonium bromide; sodium hydrogencarbonate; palladium on activated charcoal; In tetrahydrofuran; ethanol; water; ethyl acetate; 4: Henry reaction;
DOI:10.1016/j.tet.2006.03.063