ethyl (5-ethoxycarbonyl-4-methyl-2-phenylpyrimidin-6-yl)thioacetate

Base Information

• Chemical Name: ethyl (5-ethoxycarbonyl-4-methyl-2-phenylpyrimidin-6-yl)thioacetate
• CAS No.: 126087-33-0
• Molecular Formula: C₁₈H₂₀N₂O₄S
• Molecular Weight: 360.434
• Mol file: 126087-33-0.mol

Synonyms:ethyl (5-ethoxycarbonyl-4-methyl-2-phenylpyrimidin-6-yl)thioacetate

Chemical Property of ethyl (5-ethoxycarbonyl-4-methyl-2-phenylpyrimidin-6-yl)thioacetate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of ethyl (5-ethoxycarbonyl-4-methyl-2-phenylpyrimidin-6-yl)thioacetate

There total 4 articles about ethyl (5-ethoxycarbonyl-4-methyl-2-phenylpyrimidin-6-yl)thioacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 3-aminobut-2-enoate (626-34-6) → ethyl (5-ethoxycarbonyl-4-methyl-2-phenylpyrimidin-6-yl)thioacetate (126087-33-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 67 percent / acetone / 2 h / Heating

2: AcONa / ethanol / 2 h / Heating

With sodium acetate; In ethanol; acetone;

DOI:10.1002/jccs.200200152

Reference yield:

Benzoyl isothiocyanate (532-55-8) → ethyl (5-ethoxycarbonyl-4-methyl-2-phenylpyrimidin-6-yl)thioacetate (126087-33-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 67 percent / acetone / 2 h / Heating

2: AcONa / ethanol / 2 h / Heating

With sodium acetate; In ethanol; acetone;

DOI:10.1002/jccs.200200152

Reference yield:

ethyl 4-methyl-2-phenyl-6-thioxo-1,6-dihydro-5-pyrimidinecarboxylate (23155-55-7) → ethyl (5-ethoxycarbonyl-4-methyl-2-phenylpyrimidin-6-yl)thioacetate (126087-33-0)

Guidance literature:

With sodium acetate; In ethanol; for 2h; Heating;

DOI:10.1080/10426500214894

upstream raw materials:

ethyl 4-methyl-2-phenyl-6-thioxo-1,6-dihydro-5-pyrimidinecarboxylate

chloroacetic acid ethyl ester

ethyl 3-aminobut-2-enoate

Benzoyl isothiocyanate

Downstream raw materials:

2-[5-ethoxycarbonyl-4-methyl-2-phenylpyrimidin-6-yl]mercaptoacetichydrazide

3-hydroxy-4-methyl-1[H]-6-phenylpyrazolo[3,4-d]pyrimidin