1H-Benzimidazole,4,6-dichloro-(9CI)

Base Information

• Chemical Name: 1H-Benzimidazole,4,6-dichloro-(9CI)
• CAS No.: 82326-55-4
• Molecular Formula: C7H4 Cl2 N2
• Molecular Weight: 187.03
• Hs Code.: 2933299090
• Mol file: 82326-55-4.mol

Synonyms:1H-Benzimidazole,4,6-dichloro- (9CI); Benzimidazole, 4,6(or 5,7)-dichloro- (6CI); NSC 240759

Chemical Property of 1H-Benzimidazole,4,6-dichloro-(9CI)

Chemical Property:

• PSA: 28.68000
• LogP: 2.86970

Purity/Quality:

99%min. ^*data from raw suppliers

5,7-Dichloro-1H-benzo[d]imidazole 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Benzimidazole,4,6-dichloro-(9CI)

There total 6 articles about 1H-Benzimidazole,4,6-dichloro-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

formic acid (64-18-6) + 3,5-dichloro-2-nitroaniline (122584-83-2) → 4,6-dichloro-1H-benzo[d]imidazole (82326-55-4)

Guidance literature:

With tin(ll) chloride; at 130 ℃; for 0.0833333h; microwave;

DOI:10.1016/j.tetlet.2005.07.130

Reference yield: 88.4%

→ 4,6-dichloro-1H-benzo[d]imidazole (82326-55-4)

Guidance literature:

In water; at 100 ℃; for 3h;

Reference yield:

3,5-dichloro-1,2-phenylenediamine (5233-04-5) + trimethyl orthoformate (149-73-5) → 4,6-dichloro-1H-benzo[d]imidazole (82326-55-4)

Guidance literature:

at 120 ℃; for 8h;

upstream raw materials:

formic acid

3,5-dichloro-1,2-phenylenediamine

3,5-dichloro-2-nitroaniline

trimethyl orthoformate

Downstream raw materials:

2-[(4-bromo-phenyl)-piperidin-4-ylidene-methyl]-4,6-dichloro-1H-benzoimidazole

4-[(4-bromo-phenyl)-(4,6-dichloro-1H-benzoimidazol-2-yl)-methylene]-piperidine-1-carboxylic acid tert-butyl ester

4'-[(4,6-dichloro-1H-benzoimidazol-2-yl)-piperidin-4-ylidene-methyl]-biphenyl-3-carbonitrile