5-<(tert-Butyldimethylsilyl)oxy>-1-hydroxy-1-(4'-methoxyphenyl)-2-pentyne

Base Information

Chemical Name:5-<(tert-Butyldimethylsilyl)oxy>-1-hydroxy-1-(4'-methoxyphenyl)-2-pentyne
CAS No.:168071-44-1
Molecular Formula:C₁₈H₂₈O₃Si
Molecular Weight:320.504
Hs Code.:

Synonyms:5-<(tert-Butyldimethylsilyl)oxy>-1-hydroxy-1-(4'-methoxyphenyl)-2-pentyne

Suppliers and Price of 5-<(tert-Butyldimethylsilyl)oxy>-1-hydroxy-1-(4'-methoxyphenyl)-2-pentyne

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-<(tert-Butyldimethylsilyl)oxy>-1-hydroxy-1-(4'-methoxyphenyl)-2-pentyne

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Technology Process of 5-<(tert-Butyldimethylsilyl)oxy>-1-hydroxy-1-(4'-methoxyphenyl)-2-pentyne

There total 2 articles about 5-<(tert-Butyldimethylsilyl)oxy>-1-hydroxy-1-(4'-methoxyphenyl)-2-pentyne which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 78592-82-2
4-(tert-butyldimethylsilyloxy)-1-butyne

: 123-11-5
4-methoxy-benzaldehyde

: 168071-44-1
5-<(tert-Butyldimethylsilyl)oxy>-1-hydroxy-1-(4'-methoxyphenyl)-2-pentyne

Guidance literature:: With n-butyllithium; In tetrahydrofuran; hexane; 1.) -78 deg C, 5 min; r.t., 20 min, 2.) -78 deg C, 1 h;
DOI:10.1021/jo00111a039

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 168071-44-1
5-<(tert-Butyldimethylsilyl)oxy>-1-hydroxy-1-(4'-methoxyphenyl)-2-pentyne

Guidance literature:: Multi-step reaction with 2 steps

1.1: imidazole; DMAP / dimethylformamide

2.1: ethylmagnesium bromide / tetrahydrofuran; diethyl ether / 4 h / 0 °C

2.2: 44 percent / diethyl ether; tetrahydrofuran / 2 h / 0 °C

With 1H-imidazole; dmap; ethylmagnesium bromide; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide; 1.1: silylation / 2.1: Metallation / 2.2: Grignard reaction;
DOI:10.1016/S0040-4020(97)00786-2