tert-butyl 2-[3-(2,2-dimethylpropionylamino)-2-methoxycarbonylphenyl-ethynyl]-pyrrolidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 2-[3-(2,2-dimethylpropionylamino)-2-methoxycarbonylphenyl-ethynyl]-pyrrolidine-1-carboxylate
CAS No.:1411983-06-6
Molecular Formula:C₂₄H₃₂N₂O₅
Molecular Weight:428.528
Hs Code.:

Synonyms:tert-butyl 2-[3-(2,2-dimethylpropionylamino)-2-methoxycarbonylphenyl-ethynyl]-pyrrolidine-1-carboxylate

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Chemical Property of tert-butyl 2-[3-(2,2-dimethylpropionylamino)-2-methoxycarbonylphenyl-ethynyl]-pyrrolidine-1-carboxylate

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Technology Process of tert-butyl 2-[3-(2,2-dimethylpropionylamino)-2-methoxycarbonylphenyl-ethynyl]-pyrrolidine-1-carboxylate

There total 5 articles about tert-butyl 2-[3-(2,2-dimethylpropionylamino)-2-methoxycarbonylphenyl-ethynyl]-pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1411983-07-7
methyl 2-(2,2-dimethylpropionylamino)-6-trifluoromethanesulfonyloxy-benzoate

: 1411983-09-9
tert-butyl 2-tributylstannanylethynyl-pyrrolidine-1-carboxylate

: 1411983-06-6
tert-butyl 2-[3-(2,2-dimethylpropionylamino)-2-methoxycarbonylphenyl-ethynyl]-pyrrolidine-1-carboxylate

Guidance literature:: With lithium chloride; bis-triphenylphosphine-palladium(II) chloride; In N,N-dimethyl-formamide; at 95 ℃; for 1h; Inert atmosphere;

Reference yield:

: 3282-30-2
pivaloyl chloride

: 1411983-06-6
tert-butyl 2-[3-(2,2-dimethylpropionylamino)-2-methoxycarbonylphenyl-ethynyl]-pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydrogencarbonate / ethyl acetate; water

2: pyridine / dichloromethane / 1 h / Cooling with ice

3: lithium chloride / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 1 h / 95 °C / Inert atmosphere

With pyridine; sodium hydrogencarbonate; lithium chloride; bis-triphenylphosphine-palladium(II) chloride; In dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 316141-37-4
(R)-2-ethynyl-1-pyrrolidinecarboxylic acid,1,1-dimethylethyl ester

: 1411983-06-6
tert-butyl 2-[3-(2,2-dimethylpropionylamino)-2-methoxycarbonylphenyl-ethynyl]-pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran / 1 h / -78 - -30 °C / Inert atmosphere

1.2: -30 - -10 °C

2.1: lithium chloride / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 1 h / 95 °C / Inert atmosphere

With n-butyllithium; lithium chloride; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; N,N-dimethyl-formamide;