3-(5-bromo-2-fluorophenyl)-1,3-dimethylpiperazine-2,5-dione

Base Information

• Chemical Name: 3-(5-bromo-2-fluorophenyl)-1,3-dimethylpiperazine-2,5-dione
• CAS No.: 1313525-72-2
• Molecular Formula: C₁₂H₁₂BrFN₂O₂
• Molecular Weight: 315.142
• Mol file: 1313525-72-2.mol

Synonyms:3-(5-bromo-2-fluorophenyl)-1,3-dimethylpiperazine-2,5-dione

Chemical Property of 3-(5-bromo-2-fluorophenyl)-1,3-dimethylpiperazine-2,5-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(5-bromo-2-fluorophenyl)-1,3-dimethylpiperazine-2,5-dione

There total 6 articles about 3-(5-bromo-2-fluorophenyl)-1,3-dimethylpiperazine-2,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(5-bromo-2-fluorophenyl)-2-(2-chloroacetylamino)propionic acid methyl ester (1313525-71-1) + methylamine (74-89-5) → 3-(5-bromo-2-fluorophenyl)-1,3-dimethylpiperazine-2,5-dione (1313525-72-2)

Guidance literature:

In ethanol; at 50 ℃; for 1.5h;

Reference yield:

1-(5-bromo-2-fluorophenyl)ethan-1-one (198477-89-3) → 3-(5-bromo-2-fluorophenyl)-1,3-dimethylpiperazine-2,5-dione (1313525-72-2)

Guidance literature:

Multi-step reaction with 6 steps

1.1: ammonium hydroxide; ammonium chloride / water / 20 °C

1.2: Reflux

2.1: hydrogenchloride; water / Reflux

3.1: sodium hydroxide / water

4.1: thionyl chloride / -10 °C

4.2: 18 h / Reflux

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1.5 h / -5 °C

6.1: ethanol / 1.5 h / 50 °C

With hydrogenchloride; ammonium hydroxide; thionyl chloride; water; ammonium chloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In ethanol; dichloromethane; water;

Reference yield:

rac-2-amino-2-(5-bromo-2-fluoro-phenyl)-propionic acid methyl ester (1266784-18-2) → 3-(5-bromo-2-fluorophenyl)-1,3-dimethylpiperazine-2,5-dione (1313525-72-2)

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1.5 h / -5 °C

2: ethanol / 1.5 h / 50 °C

With N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane;

upstream raw materials:

2-(5-bromo-2-fluorophenyl)-2-(2-chloroacetylamino)propionic acid methyl ester

methylamine

1-(5-bromo-2-fluorophenyl)ethan-1-one

rac-2-amino-2-(5-bromo-2-fluoro-phenyl)-propionic acid methyl ester

Downstream raw materials:

3-(5-bromo-2-fluorophenyl)-1,3-dimethyl-5-thioxopiperazin-2-one

5-amino-3-(5-bromo-2-fluorophenyl)-1,3-dimethyl-3,6-dihydro-1H-pyrazin-2-one

[6-(5-bromo-2-fluorophenyl)-4,6-dimethyl-5-oxo-3,4,5,6-tetrahydropyrazin-2-yl]carbamic acid tert-butyl ester

[6-(5-amino-2-fluorophenyl)-4,6-dimethyl-5-oxo-3,4,5,6-tetrahydropyrazin-2-yl]carbamic acid tert-butyl ester