5-bromo-1-(phenylsulfonyl)-2-(trimethylsilyl)-1H-pyrrolo[2,3-b]pyridine

Base Information

• Chemical Name: 5-bromo-1-(phenylsulfonyl)-2-(trimethylsilyl)-1H-pyrrolo[2,3-b]pyridine
• CAS No.: 1305324-90-6
• Molecular Formula: C₁₆H₁₇BrN₂O₂SSi
• Molecular Weight: 409.379

Synonyms:5-bromo-1-(phenylsulfonyl)-2-(trimethylsilyl)-1H-pyrrolo[2,3-b]pyridine

Chemical Property of 5-bromo-1-(phenylsulfonyl)-2-(trimethylsilyl)-1H-pyrrolo[2,3-b]pyridine

Chemical Property:

Purity/Quality:

98%min ^*data from raw suppliers

5-Bromo-1-(phenylsulfonyl)-2-(trimethylsilyl)-1H-pyrrolo[2,3-b]pyridine ^*data from reagent suppliers

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Technology Process of 5-bromo-1-(phenylsulfonyl)-2-(trimethylsilyl)-1H-pyrrolo[2,3-b]pyridine

There total 3 articles about 5-bromo-1-(phenylsulfonyl)-2-(trimethylsilyl)-1H-pyrrolo[2,3-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

chloro-trimethyl-silane (75-77-4) + 1-(benzenesulfonyl)-5-bromo-1H-pyrrolo[2,3-b]pyridine (1001070-33-2) → 5-bromo-1-(phenylsulfonyl)-2-(trimethylsilyl)-1H-pyrrolo[2,3-b]pyridine (1305324-90-6)

Guidance literature:

1-(benzenesulfonyl)-5-bromo-1H-pyrrolo[2,3-b]pyridine; With lithium diisopropyl amide; In tetrahydrofuran; at -78 - -70 ℃; for 1.5h;

chloro-trimethyl-silane; In tetrahydrofuran; at -78 - 20 ℃; for 4h;

Reference yield:

benzenesulfonyl chloride (98-09-9) → 5-bromo-1-(phenylsulfonyl)-2-(trimethylsilyl)-1H-pyrrolo[2,3-b]pyridine (1305324-90-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C

1.2: 16 h / 20 °C

2.1: lithium diisopropyl amide / tetrahydrofuran / 1.5 h / -78 - -70 °C

2.2: 4 h / -78 - 20 °C

With sodium hydride; lithium diisopropyl amide; In tetrahydrofuran; mineral oil;

Reference yield:

5-bromo-1H-pyrrolo[2,3-b]pyridine (183208-35-7) → 5-bromo-1-(phenylsulfonyl)-2-(trimethylsilyl)-1H-pyrrolo[2,3-b]pyridine (1305324-90-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C

1.2: 16 h / 20 °C

2.1: lithium diisopropyl amide / tetrahydrofuran / 1.5 h / -78 - -70 °C

2.2: 4 h / -78 - 20 °C

With sodium hydride; lithium diisopropyl amide; In tetrahydrofuran; mineral oil;

upstream raw materials:

chloro-trimethyl-silane

1-(benzenesulfonyl)-5-bromo-1H-pyrrolo[2,3-b]pyridine

benzenesulfonyl chloride

5-bromo-1H-pyrrolo[2,3-b]pyridine

Downstream raw materials:

5-bromo(2,3-2H₂)-1H-pyrrolo[2,3-b]pyridine

5-bromo-1-(phenylsulfonyl)(2,3-2H₂)-1H-pyrrolo[2,3-b]pyridine

5-bromo-3-{[2-chloro-6-(difluoromethoxy)-3-fluorophenyl](methoxy)methyl}(2-2H)-1H-pyrrolo[2,3-b]pyridine

[5-bromo(2-2H)-1H-pyrrolo[2,3-b]pyridin-3-yl][2-chloro-6-(difluoromethoxy)-3-fluorophenyl]methanol

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