5-chloro-N-[1-[(3-cyanophenyl)methyl]-6-fluoro-4-(methyloxy)-1H-indazol-3-yl]-2-thiophenesulfonamide

Base Information

Chemical Name:5-chloro-N-[1-[(3-cyanophenyl)methyl]-6-fluoro-4-(methyloxy)-1H-indazol-3-yl]-2-thiophenesulfonamide
CAS No.:1240518-44-8
Molecular Formula:C₂₀H₁₄ClFN₄O₃S₂
Molecular Weight:476.94
Hs Code.:

Synonyms:5-chloro-N-[1-[(3-cyanophenyl)methyl]-6-fluoro-4-(methyloxy)-1H-indazol-3-yl]-2-thiophenesulfonamide

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Chemical Property of 5-chloro-N-[1-[(3-cyanophenyl)methyl]-6-fluoro-4-(methyloxy)-1H-indazol-3-yl]-2-thiophenesulfonamide

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Technology Process of 5-chloro-N-[1-[(3-cyanophenyl)methyl]-6-fluoro-4-(methyloxy)-1H-indazol-3-yl]-2-thiophenesulfonamide

There total 6 articles about 5-chloro-N-[1-[(3-cyanophenyl)methyl]-6-fluoro-4-(methyloxy)-1H-indazol-3-yl]-2-thiophenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 2766-74-7
5-chlorothien-2-ylsulfonyl chloride

: 1240518-43-7
3-{[3-amino-6-fluoro-4-(methyloxy)-1H-indazol-1-yl]methyl}benzonitrile

: 1240518-44-8
5-chloro-N-[1-[(3-cyanophenyl)methyl]-6-fluoro-4-(methyloxy)-1H-indazol-3-yl]-2-thiophenesulfonamide

Guidance literature:: With pyridine; In chloroform; at 20 ℃; for 5h;
DOI:10.1021/jm301572h

Reference yield:

: 2766-74-7
5-chlorothien-2-ylsulfonyl chloride

: 1240518-43-7
3-{[3-amino-6-fluoro-4-(methyloxy)-1H-indazol-1-yl]methyl}benzonitrile

: 1240518-44-8
5-chloro-N-[1-[(3-cyanophenyl)methyl]-6-fluoro-4-(methyloxy)-1H-indazol-3-yl]-2-thiophenesulfonamide

: 1240518-45-9
5-chloro-N-[(5-chloro-2-thienyl)sulfonyl]-N-[1-[(3-cyanophenyl)methyl]-6-fluoro-4-(methyloxy)-1H-indazol-3-yl]-2-thiophenesulfonamide

Guidance literature:: With pyridine; In chloroform; at 20 ℃; for 5h;

Reference yield:

: 93343-10-3
3,5-difluoroanisol

: 1240518-44-8
5-chloro-N-[1-[(3-cyanophenyl)methyl]-6-fluoro-4-(methyloxy)-1H-indazol-3-yl]-2-thiophenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: titanium chloride / dichloromethane / 0.25 h

2.1: hydroxylamine-O-sulfonic acid / water / 3 h / 110 °C

3.1: hydrazine hydrate / butan-1-ol / 23 h / 110 - 115 °C

4.1: potassium hydroxide / dimethyl sulfoxide / 0.17 h

4.2: 1 h

5.1: pyridine / chloroform / 5 h / 20 °C

With pyridine; titanium chloride; hydrazine hydrate; potassium hydroxide; hydroxylamine-O-sulfonic acid; In dichloromethane; chloroform; water; dimethyl sulfoxide; butan-1-ol;
DOI:10.1021/jm301572h